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Gene Review

Rgs19  -  regulator of G-protein signaling 19

Mus musculus

Synonyms: 2610042F04Rik, AI324841, AW547781, GAIP, RGS19, ...
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High impact information on Rgs19

  • In the same assays, the N-terminally truncated GAIP/RGS19 did not distinguish ORL1 from the mu, delta, and kappa opioid receptors [1].
  • Knockdown of GAIP and of the GAIP interacting protein C-terminus (GIPC) led to changes in agonist effects at mu but not at delta receptors [2].
  • In the CNS, the regulators of G-protein signaling (RGS) proteins belonging to the Rz subfamily, RGS19 (G(alpha) interacting protein (GAIP)) and RGS20 (Z1), control the activity of opioid agonists at mu but not at delta receptors [2].
  • RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance [2].

Regulatory relationships of Rgs19

  • By contrast, expression of RGS19 did not inhibit activation of Lef-Tcf gene transcription when induced in response to Dvl3 expression [3].


  1. N-terminally truncated variant of the mouse GAIP/RGS19 lacks selectivity of full-length GAIP/RGS19 protein in regulating ORL1 receptor signaling. Xie, G.X., Yanagisawa, Y., Ito, E., Maruyama, K., Han, X., Kim, K.J., Han, K.R., Moriyama, K., Palmer, P.P. J. Mol. Biol. (2005) [Pubmed]
  2. RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Garzón, J., Rodríguez-Muñoz, M., López-Fando, A., García-España, A., Sánchez-Blázquez, P. Neuropsychopharmacology (2004) [Pubmed]
  3. RGS19 regulates Wnt-beta-catenin signaling through inactivation of Galpha(o). Feigin, M.E., Malbon, C.C. J. Cell. Sci. (2007) [Pubmed]
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