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MeSH Review


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Disease relevance of Tachyphylaxis


Psychiatry related information on Tachyphylaxis


High impact information on Tachyphylaxis


Chemical compound and disease context of Tachyphylaxis


Biological context of Tachyphylaxis


Anatomical context of Tachyphylaxis


Associations of Tachyphylaxis with chemical compounds


Gene context of Tachyphylaxis

  • Tachyphylaxis was dose dependent with each and also between the IL-1 species; therefore, when tachyphylaxis between the cytokines and LPS was examined, relatively higher doses were selected for the desensitizing injections than for the test injections [31].
  • 7. Repeated injections of submaximal doses of ET-1 or SX6C caused tachyphylaxis to vasodilator responses [32].
  • 4. Rats given a 10 min infusion (0.1 nmol kg-1 min-1) of endothelin-1 showed no hypotensive response to an i.v. bolus injection of endothelin-1, whereas animals pretreated with an equipressor infusion of h-proendothelin did not develop tachyphylaxis to endothelin-1 [33].
  • Tachyphylaxis to SST analogues was considered [34].
  • In contrast, the inhibitory effects induced by NPY and APP usually returned to the control level after 20-30 min and had minimal tachyphylaxis [35].

Analytical, diagnostic and therapeutic context of Tachyphylaxis


  1. Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure. Packer, M., Meller, J., Gorlin, R., Herman, M.V. Circulation (1979) [Pubmed]
  2. Prolonged duration of blood pressure response to enalkiren, the novel dipeptide renin inhibitor, in essential hypertension. Boger, R.S., Glassman, H.N., Cavanaugh, J.H., Schmitz, P.J., Lamm, J., Moyse, D., Cohen, A., Kleinert, H.D., Luther, R.R. Hypertension (1990) [Pubmed]
  3. Pain and hyperalgesia after intradermal injection of bradykinin in humans. Manning, D.C., Raja, S.N., Meyer, R.A., Campbell, J.N. Clin. Pharmacol. Ther. (1991) [Pubmed]
  4. Effect of age and spontaneous hypertension on the tachyphylaxis to 5-hydroxytryptamine and angiotensin II in the isolated rat kidney. De Mey, C., Vanhoutte, P.M. Hypertension (1981) [Pubmed]
  5. Role of prostanoids in the regulation of central cholinergic receptor sensitivity. Buccafusco, J.J., Lapp, C.A., Aronstam, R.S., Hays, A.C., Shuster, L.C. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  6. Beta-adrenergic agonists reduce spontaneous motor activity through either beta 1 or beta 2 receptors. Frances, H., Renwart, N., Danti, S., Cash, R., Raisman, R., Simon, P. Pharmacol. Biochem. Behav. (1987) [Pubmed]
  7. Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. Theoharides, T.C., Sieghart, W., Greengard, P., Douglas, W.W. Science (1980) [Pubmed]
  8. Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission. Mashimo, H., He, X.D., Huang, P.L., Fishman, M.C., Goyal, R.K. J. Clin. Invest. (1996) [Pubmed]
  9. Interactions of bombesin and substance P at the feline lower esophageal sphincter. Reynolds, J.C., Dukehart, M.R., Ouyang, A., Cohen, S. J. Clin. Invest. (1986) [Pubmed]
  10. Neural control of the sphincter of Oddi. A physiological role of 5-hydroxytryptamine in the regulation of basal sphincter of Oddi motor activity in the cat. Behar, J., Biancani, P. J. Clin. Invest. (1983) [Pubmed]
  11. Assessment of tachyphylaxis following prolonged therapy of asthma with inhaled albuterol aerosol. Repsher, L.H., Anderson, J.A., Bush, R.K., Falliers, C.J., Kass, I., Kemp, J.P., Reed, C., Siegel, S., Webb, D.R. Chest (1984) [Pubmed]
  12. Role of plasmin, thrombin, and antithrombin III as etiological factors in delayed cerebral vasospasm. White, R.P., Robertson, J.T. Neurosurgery (1985) [Pubmed]
  13. Systemic and cerebral effects of prostacyclin-induced arterial hypotension in the dog. Boarini, D.J., Kassell, N.F., Olin, J.J., Sprowell, J.A. J. Neurosurg. (1984) [Pubmed]
  14. Strategies to optimize efficacy, duration of remission, and safety in the treatment of plaque psoriasis by using tazarotene in combination with a corticosteroid. Lebwohl, M. J. Am. Acad. Dermatol. (2000) [Pubmed]
  15. Long-term propranolol therapy for angina pectoris. Warren, S.G., Brewer, D.L., Orgain, E.S. Am. J. Cardiol. (1976) [Pubmed]
  16. Repeated inhalation challenge with exogenous and endogenous histamine released by acetaldehyde inhalation in asthmatic patients. Myou, S., Fujimura, M., Kamio, Y., Bando, T., Nakatsumi, Y., Matsuda, T. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  17. Inhibitory effect of indomethacin on tachyphylaxis in response to acetaldehyde-induced bronchoconstriction in patients with asthma. Fujimura, M., Myou, S., Kamio, Y., Matsuda, T. J. Allergy Clin. Immunol. (1997) [Pubmed]
  18. Characterization of agonist-induced motilin receptor trafficking and its implications for tachyphylaxis. Lamian, V., Rich, A., Ma, Z., Li, J., Seethala, R., Gordon, D., Dubaquie, Y. Mol. Pharmacol. (2006) [Pubmed]
  19. Possible mechanism of acetaldehyde-induced noradrenaline release from sympathetic nerve terminals in isolated blood vessels. Chiba, S., Tsukada, M. Br. J. Pharmacol. (1988) [Pubmed]
  20. Lack of cardiac or bronchodilator tachyphylaxis to isoprenaline in the dog. Minatoya, H., Spilker, B.A. Br. J. Pharmacol. (1975) [Pubmed]
  21. C4a: the third anaphylatoxin of the human complement system. Gorski, J.P., Hugli, T.E., Müller-Eberhard, H.J. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  22. Rapid mobilization of hematopoietic progenitor cells in rhesus monkeys by a single intravenous injection of interleukin-8. Laterveer, L., Lindley, I.J., Heemskerk, D.P., Camps, J.A., Pauwels, E.K., Willemze, R., Fibbe, W.E. Blood (1996) [Pubmed]
  23. Induction and maintenance of monocyte cytotoxicity during treatment with liposomes containing muramyl tripeptide despite tachyphylaxis to the cytokine response. Galligioni, E., Favaro, D., Santarosa, M., Quaia, M., Spada, A., Freschi, A., Alberti, D. Clin. Cancer Res. (1995) [Pubmed]
  24. The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat. Albinus, M., Blair, E.L., Hirst, B.H., Reed, J.D., Schally, A.V., Shaw, B. J. Physiol. (Lond.) (1977) [Pubmed]
  25. Increased synthesis of prostaglandin-like material during histamine tachyphylaxis in canine tracheal smooth muscle. Anderson, W.H., Krzanowski, J.J., Polson, J.B., Szentivanyi, A. Biochem. Pharmacol. (1979) [Pubmed]
  26. Rapid development of renal resistance to low doses of synthetic bovine parathyroid hormone fragment 1-34. Dissociation of urinary cyclic adenosine monophosphate, phosphaturic, and calciuric responses. Law, W.M., Heath, H. J. Clin. Invest. (1983) [Pubmed]
  27. gamma-Aminobutyric acid stimulates electrolyte transport in the guinea pig ileum in vitro. MacNaughton, W.K., Pineau, B.C., Krantis, A. Gastroenterology (1996) [Pubmed]
  28. Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum. Takeuchi, K., Matsumoto, J., Ueshima, K., Okabe, S. Gastroenterology (1991) [Pubmed]
  29. Effect of nicotine on the lower esophageal sphincter. Studies on the mechanism of action. Rattan, S., Goyal, R.K. Gastroenterology (1975) [Pubmed]
  30. Neural control of the sphincter of Oddi. Physiologic role of enkephalins on the regulation of basal sphincter of Oddi motor activity in the cat. Behar, J., Biancani, P. Gastroenterology (1984) [Pubmed]
  31. Neutrophil leukocyte emigration induced by endotoxin. Mediator roles of interleukin 1 and tumor necrosis factor alpha 1. Cybulsky, M.I., McComb, D.J., Movat, H.Z. J. Immunol. (1988) [Pubmed]
  32. Investigation of the contributions of nitric oxide and prostaglandins to the actions of endothelins and sarafotoxin 6c in rat isolated perfused lungs. Lal, H., Woodward, B., Williams, K.I. Br. J. Pharmacol. (1996) [Pubmed]
  33. Cross tachyphylaxis to endothelin isopeptide-induced hypotension: a phenomenon not seen with proendothelin. Le Monnier de Gouville, A.C., Cavero, I. Br. J. Pharmacol. (1991) [Pubmed]
  34. Partial tachyphylaxis to somatostatin (SST) analogues in a patient with acromegaly: the role of SST receptor desensitisation and circulating antibodies to SST analogues. Wahid, S.T., Marbach, P., Stolz, B., Miller, M., James, R.A., Ball, S.G. Eur. J. Endocrinol. (2002) [Pubmed]
  35. The effects of pancreatic polypeptides and neuropeptide Y on the rat vas deferens. Ohhashi, T., Jacobowitz, D.M. Peptides (1983) [Pubmed]
  36. Dual reuptake inhibitors incur lower rates of tachyphylaxis than selective serotonin reuptake inhibitors: a retrospective study. Posternak, M.A., Zimmerman, M. The Journal of clinical psychiatry. (2005) [Pubmed]
  37. Mechanism of the indirect sympathomimetic effect of 5-hydroxytrypt-amine on the isolated heart of the rabbit. Fozard, J.R., Mwaluko, G.M. Br. J. Pharmacol. (1976) [Pubmed]
  38. The development of tachyphylaxis to electrical stimulation in guinea-pig ileal longitudinal muscles and the possible participation of adenosine and adenine nucleotides. Hayashi, E., Kunitomo, M., Mori, M., Shinozuka, K., Yamada, S. Br. J. Pharmacol. (1978) [Pubmed]
  39. Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. Lin, G., Xin, Z.C., Lue, T.F., Lin, C.S. J. Urol. (2003) [Pubmed]
  40. Regional variation in acute vascular homologous tachyphylaxis. Miao, F.J., Lee, T.J. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
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