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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EIF4ENIF1  -  eukaryotic translation initiation factor...

Homo sapiens

Synonyms: 2610509L04Rik, 4E-T, Clast4, Eukaryotic translation initiation factor 4E nuclear import factor 1, Eukaryotic translation initiation factor 4E transporter, ...
 
 
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Disease relevance of EIF4ENIF1

  • Out of 39 patients [18 polycythaemia vera (PV), 13 essential thrombocythaemia (ET), 4 chronic myeloid leukemia (CML), 4 undefined myeloproliferative diseases (MPD)] treated with hydroxyurea, 6 (4ET, 1PV, 1CML) developed a cutaneous ulcer during a period of less that 2 years' treatment [1].
 

High impact information on EIF4ENIF1

  • The 4E-T binding partner, eIF4E, also is localized in P-bodies [2].
  • Moreover, 4E-T controls mRNA half-life, because its depletion from cells using short interfering RNA increases mRNA stability [2].
  • A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E [3].
  • Overexpression of wild-type 4E-T, but not of a mutant defective for eIF4E binding, causes the nuclear accumulation of HA-eIF4E in cells treated with leptomycin B [3].
 

Biological context of EIF4ENIF1

  • At steady state, 4E-T is predominantly cytoplasmic and is concentrated in bodies that conspicuously resemble the recently described processing bodies (P-bodies), which are believed to be sites of mRNA decay [2].

References

  1. Leg ulcer in hydroxyurea-treated patients. Poros, A., Nádasdy, K. Haematologia (Budap) (2000) [Pubmed]
  2. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. Ferraiuolo, M.A., Basak, S., Dostie, J., Murray, E.L., Schoenberg, D.R., Sonenberg, N. J. Cell Biol. (2005) [Pubmed]
  3. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. Dostie, J., Ferraiuolo, M., Pause, A., Adam, S.A., Sonenberg, N. EMBO J. (2000) [Pubmed]
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