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MeSH Review

RNA Stability

 
 
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Disease relevance of RNA Stability

 

Psychiatry related information on RNA Stability

  • However, formalin fixation has three disadvantages: (1) slow fixation (16-24 h) hinders intraoperative decision making, (2) slow quenching of enzymatic activity causes RNA degradation, and (3) extensive molecule modification affects protein antigenicity [6].
 

High impact information on RNA Stability

  • TTP does not directly bind to miR16 but interacts through association with Ago/eiF2C family members to complex with miR16 and assists in the targeting of ARE. miRNA targeting of ARE, therefore, appears to be an essential step in ARE-mediated mRNA degradation [7].
  • Stau1 binds directly to Upf1 and elicits mRNA decay when tethered downstream of a termination codon [8].
  • Here we describe an mRNA decay mechanism that involves Stau1, the NMD factor Upf1, and a termination codon [8].
  • Poly(A) tails stimulate RNA degradation in bacteria, suggesting that this is their ancestral function [9].
  • Involvement of microRNA in AU-rich element-mediated mRNA instability [7].
 

Chemical compound and disease context of RNA Stability

 

Biological context of RNA Stability

  • Transgenic Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone synthase activity and purple flower pigment through posttranscriptional chsA RNA degradation [15].
  • The sensitivity of RNase E to 5'-terminal base pairing may explain how determinants near the 5' end can control rates of mRNA decay in bacteria [16].
  • Certain hormones cause specific stabilization of mRNAs species and preferential mRNA stability is important in the accumulation of globin and myosin mRNAs during the terminal stages of erythropoesis or myogenesis, respectively [17].
  • Therefore, ASF/SF2, and perhaps other SR proteins, affects gene expression in vertebrate cells through regulation of mRNA stability as well as splicing [18].
  • Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay [19].
 

Anatomical context of RNA Stability

 

Associations of RNA Stability with chemical compounds

 

Gene context of RNA Stability

 

Analytical, diagnostic and therapeutic context of RNA Stability

References

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