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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

RNA Stability

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Disease relevance of RNA Stability


Psychiatry related information on RNA Stability

  • However, formalin fixation has three disadvantages: (1) slow fixation (16-24 h) hinders intraoperative decision making, (2) slow quenching of enzymatic activity causes RNA degradation, and (3) extensive molecule modification affects protein antigenicity [6].

High impact information on RNA Stability

  • TTP does not directly bind to miR16 but interacts through association with Ago/eiF2C family members to complex with miR16 and assists in the targeting of ARE. miRNA targeting of ARE, therefore, appears to be an essential step in ARE-mediated mRNA degradation [7].
  • Stau1 binds directly to Upf1 and elicits mRNA decay when tethered downstream of a termination codon [8].
  • Here we describe an mRNA decay mechanism that involves Stau1, the NMD factor Upf1, and a termination codon [8].
  • Poly(A) tails stimulate RNA degradation in bacteria, suggesting that this is their ancestral function [9].
  • Involvement of microRNA in AU-rich element-mediated mRNA instability [7].

Chemical compound and disease context of RNA Stability


Biological context of RNA Stability

  • Transgenic Petunia plants with a chsA coding sequence under the control of a 35S promoter sometimes lose endogene and transgene chalcone synthase activity and purple flower pigment through posttranscriptional chsA RNA degradation [15].
  • The sensitivity of RNase E to 5'-terminal base pairing may explain how determinants near the 5' end can control rates of mRNA decay in bacteria [16].
  • Certain hormones cause specific stabilization of mRNAs species and preferential mRNA stability is important in the accumulation of globin and myosin mRNAs during the terminal stages of erythropoesis or myogenesis, respectively [17].
  • Therefore, ASF/SF2, and perhaps other SR proteins, affects gene expression in vertebrate cells through regulation of mRNA stability as well as splicing [18].
  • Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay [19].

Anatomical context of RNA Stability


Associations of RNA Stability with chemical compounds


Gene context of RNA Stability


Analytical, diagnostic and therapeutic context of RNA Stability


  1. Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Zhou, A., Hassel, B.A., Silverman, R.H. Cell (1993) [Pubmed]
  2. Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain. Rodriguez-Peña, A., Ibarrola, N., Iñiguez, M.A., Muñoz, A., Bernal, J. J. Clin. Invest. (1993) [Pubmed]
  3. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. Dixon, D.A., Tolley, N.D., King, P.H., Nabors, L.B., McIntyre, T.M., Zimmerman, G.A., Prescott, S.M. J. Clin. Invest. (2001) [Pubmed]
  4. Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Stevens, A., Wang, Y., Bremer, K., Zhang, J., Hoepfner, R., Antoniou, M., Schoenberg, D.R., Maquat, L.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Rare autosomal recessive cardiac valvular form of Ehlers-Danlos syndrome results from mutations in the COL1A2 gene that activate the nonsense-mediated RNA decay pathway. Schwarze, U., Hata, R., McKusick, V.A., Shinkai, H., Hoyme, H.E., Pyeritz, R.E., Byers, P.H. Am. J. Hum. Genet. (2004) [Pubmed]
  6. Ultrasound-accelerated formalin fixation of tissue improves morphology, antigen and mRNA preservation. Chu, W.S., Furusato, B., Wong, K., Sesterhenn, I.A., Mostofi, F.K., Wei, M.Q., Zhu, Z., Abbondanzo, S.L., Liang, Q. Mod. Pathol. (2005) [Pubmed]
  7. Involvement of microRNA in AU-rich element-mediated mRNA instability. Jing, Q., Huang, S., Guth, S., Zarubin, T., Motoyama, A., Chen, J., Di Padova, F., Lin, S.C., Gram, H., Han, J. Cell (2005) [Pubmed]
  8. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. Kim, Y.K., Furic, L., Desgroseillers, L., Maquat, L.E. Cell (2005) [Pubmed]
  9. RNA degradation by the exosome is promoted by a nuclear polyadenylation complex. LaCava, J., Houseley, J., Saveanu, C., Petfalski, E., Thompson, E., Jacquier, A., Tollervey, D. Cell (2005) [Pubmed]
  10. Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients. Moltó, J., Ruiz, L., Valle, M., Martinez-Picado, J., Bonjoch, A., Bravo, I., Negredo, E., Heilek-Sneider, G.M., Clotet, B. Antivir. Ther. (Lond.) (2006) [Pubmed]
  11. Peroxisome proliferator-activated receptor gamma agonists inhibit HIV-1 replication in macrophages by transcriptional and post-transcriptional effects. Hayes, M.M., Lane, B.R., King, S.R., Markovitz, D.M., Coffey, M.J. J. Biol. Chem. (2002) [Pubmed]
  12. One or more labile proteins regulate the stability of chimeric mRNAs containing the 3'-untranslated region of cholesterol-7alpha -hydroxylase mRNA. Baker, D.M., Wang, S.L., Bell, D.J., Drevon, C.A., Davis, R.A. J. Biol. Chem. (2000) [Pubmed]
  13. Protein kinase A-regulated instability site in the 3'-untranslated region of lactate dehydrogenase-A subunit mRNA. Tian, D., Huang, D., Short, S., Short, M.L., Jungmann, R.A. J. Biol. Chem. (1998) [Pubmed]
  14. Poly(A) polymerase I of Escherichia coli: characterization of the catalytic domain, an RNA binding site and regions for the interaction with proteins involved in mRNA degradation. Raynal, L.C., Carpousis, A.J. Mol. Microbiol. (1999) [Pubmed]
  15. RNA-mediated RNA degradation and chalcone synthase A silencing in petunia. Metzlaff, M., O'Dell, M., Cluster, P.D., Flavell, R.B. Cell (1997) [Pubmed]
  16. Control of RNase E-mediated RNA degradation by 5'-terminal base pairing in E. coli. Bouvet, P., Belasco, J.G. Nature (1992) [Pubmed]
  17. Cyclic AMP stabilizes a class of developmentally regulated Dictyostelium discoideum mRNAs. Mangiarotti, G., Ceccarelli, A., Lodish, H.F. Nature (1983) [Pubmed]
  18. Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Lemaire, R., Prasad, J., Kashima, T., Gustafson, J., Manley, J.L., Lafyatis, R. Genes Dev. (2002) [Pubmed]
  19. Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. Kashima, I., Yamashita, A., Izumi, N., Kataoka, N., Morishita, R., Hoshino, S., Ohno, M., Dreyfuss, G., Ohno, S. Genes Dev. (2006) [Pubmed]
  20. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Lindstein, T., June, C.H., Ledbetter, J.A., Stella, G., Thompson, C.B. Science (1989) [Pubmed]
  21. Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding. Vytvytska, O., Moll, I., Kaberdin, V.R., von Gabain, A., Bläsi, U. Genes Dev. (2000) [Pubmed]
  22. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Ford, L.P., Watson, J., Keene, J.D., Wilusz, J. Genes Dev. (1999) [Pubmed]
  23. Cytoarchitecture and the patterning of fushi tarazu expression in the Drosophila blastoderm. Edgar, B.A., Odell, G.M., Schubiger, G. Genes Dev. (1987) [Pubmed]
  24. Estrogen stabilizes vitellogenin mRNA against cytoplasmic degradation. Brock, M.L., Shapiro, D.J. Cell (1983) [Pubmed]
  25. RNA synthesis and control of cell division in the yeast S. cerevisiae. Johnston, G.C., Singer, R.A. Cell (1978) [Pubmed]
  26. Evidence for autoregulation of cystathionine gamma-synthase mRNA stability in Arabidopsis. Chiba, Y., Ishikawa, M., Kijima, F., Tyson, R.H., Kim, J., Yamamoto, A., Nambara, E., Leustek, T., Wallsgrove, R.M., Naito, S. Science (1999) [Pubmed]
  27. Nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in the CGS1 gene of Arabidopsis. Onouchi, H., Nagami, Y., Haraguchi, Y., Nakamoto, M., Nishimura, Y., Sakurai, R., Nagao, N., Kawasaki, D., Kadokura, Y., Naito, S. Genes Dev. (2005) [Pubmed]
  28. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Tang, A.H., Neufeld, T.P., Kwan, E., Rubin, G.M. Cell (1997) [Pubmed]
  29. The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Leeds, P., Peltz, S.W., Jacobson, A., Culbertson, M.R. Genes Dev. (1991) [Pubmed]
  30. Homology with Saccharomyces cerevisiae RNA14 suggests that phenotypic suppression in Drosophila melanogaster by suppressor of forked occurs at the level of RNA stability. Mitchelson, A., Simonelig, M., Williams, C., O'Hare, K. Genes Dev. (1993) [Pubmed]
  31. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Unterholzner, L., Izaurralde, E. Mol. Cell (2004) [Pubmed]
  32. Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae. Proweller, A., Butler, S. Genes Dev. (1994) [Pubmed]
  33. Global analysis of Escherichia coli RNA degradosome function using DNA microarrays. Bernstein, J.A., Lin, P.H., Cohen, S.N., Lin-Chao, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  34. Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein. Minvielle-Sebastia, L., Winsor, B., Bonneaud, N., Lacroute, F. Mol. Cell. Biol. (1991) [Pubmed]
  35. Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast carcinoma cells. Li, X.S., Rishi, A.K., Shao, Z.M., Dawson, M.I., Jong, L., Shroot, B., Reichert, U., Ordonez, J., Fontana, J.A. Cancer Res. (1996) [Pubmed]
  36. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter. Cram, E.J., Liu, B.D., Bjeldanes, L.F., Firestone, G.L. J. Biol. Chem. (2001) [Pubmed]
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