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Gene Review

KCNK12  -  potassium channel, two pore domain...

Homo sapiens

Synonyms: K2p12.1, Potassium channel subfamily K member 12, THIK-2, THIK2, Tandem pore domain halothane-inhibited potassium channel 2
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High impact information on KCNK12

  • Two cDNAs encoding novel K(+) channels, THIK-1 and THIK-2 (tandem pore domain halothane inhibited K(+) channel), were isolated from rat brain [1].
  • We also cloned a third subunit, named hTHIK-2 which is present in many tissues with high levels again in the pancreas but which could not be functionally expressed [2].
  • TWIK-1 and THIK-2 also showed significant decreases in expression that were maintained across all time points [3].


  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. Rajan, S., Wischmeyer, E., Karschin, C., Preisig-Müller, R., Grzeschik, K.H., Daut, J., Karschin, A., Derst, C. J. Biol. Chem. (2001) [Pubmed]
  2. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Girard, C., Duprat, F., Terrenoire, C., Tinel, N., Fosset, M., Romey, G., Lazdunski, M., Lesage, F. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  3. Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus. Holt, A.G., Asako, M., Keith Duncan, R., Lomax, C.A., Juiz, J.M., Altschuler, R.A. Hear. Res. (2006) [Pubmed]
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