The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

KCNK12  -  potassium channel, two pore domain...

Homo sapiens

Synonyms: K2p12.1, Potassium channel subfamily K member 12, THIK-2, THIK2, Tandem pore domain halothane-inhibited potassium channel 2
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on KCNK12

  • Two cDNAs encoding novel K(+) channels, THIK-1 and THIK-2 (tandem pore domain halothane inhibited K(+) channel), were isolated from rat brain [1].
  • We also cloned a third subunit, named hTHIK-2 which is present in many tissues with high levels again in the pancreas but which could not be functionally expressed [2].
  • TWIK-1 and THIK-2 also showed significant decreases in expression that were maintained across all time points [3].

References

  1. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. Rajan, S., Wischmeyer, E., Karschin, C., Preisig-Müller, R., Grzeschik, K.H., Daut, J., Karschin, A., Derst, C. J. Biol. Chem. (2001) [Pubmed]
  2. Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. Girard, C., Duprat, F., Terrenoire, C., Tinel, N., Fosset, M., Romey, G., Lazdunski, M., Lesage, F. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  3. Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus. Holt, A.G., Asako, M., Keith Duncan, R., Lomax, C.A., Juiz, J.M., Altschuler, R.A. Hear. Res. (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities