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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CELF4  -  CUGBP, Elav-like family member 4

Homo sapiens

Synonyms: BRUNOL-4, BRUNOL4, Bruno-like protein 4, CELF-4, CUG-BP-and ETR-3-like factor 4, ...
 
 
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High impact information on BRUNOL4

  • CUG-BP, ETR-3, and CELF4 are more broadly expressed, and expression is developmentally regulated in striated muscle and brain [1].
  • CUG-BP and ETR3 activated the SM exon, and along with CELF4 they were also able to repress splicing of the NM (nonmuscle) exon both in vivo and in vitro [2].
  • ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo [3].
 

Biological context of BRUNOL4

  • For both ETR-3 and CELF4, distinct regions were required to activate splicing of two different alternative exons, while regions required for repression of an additional third exon overlapped with regions required for activation [4].
 

Other interactions of BRUNOL4

  • We identified a 20-residue region of CELF4 required for repression or activation, in contrast to ETR-3, for which the required residues are more disperse [4].

References

  1. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Ladd, A.N., Charlet, N., Cooper, T.A. Mol. Cell. Biol. (2001) [Pubmed]
  2. Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. Gromak, N., Matlin, A.J., Cooper, T.A., Smith, C.W. RNA (2003) [Pubmed]
  3. ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Singh, G., Charlet-B, N., Han, J., Cooper, T.A. Nucleic Acids Res. (2004) [Pubmed]
  4. Identification of CELF splicing activation and repression domains in vivo. Han, J., Cooper, T.A. Nucleic Acids Res. (2005) [Pubmed]
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