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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Protein Structure, Tertiary

 
 
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Disease relevance of Protein Structure, Tertiary

 

Psychiatry related information on Protein Structure, Tertiary

 

High impact information on Protein Structure, Tertiary

  • Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin [7].
  • 1. We identified mutations in a gene encoding a 19-kDa single-transmembrane domain protein, now known as melanocortin 2 receptor accessory protein (MRAP) [8].
  • In contrast, overexpression of placental growth factor, which signals through Flt1 but not kinase insert domain protein receptors (KDRs), had negative effects on neurogenesis and inhibited learning, although it similarly increased endothelial cell proliferation [9].
  • Here, we show that a PS1-dependent gamma-secretase protease activity promotes an epsilon-like cleavage of N-cadherin to produce its intracellular domain peptide, N-Cad/CTF2 [10].
  • Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase [11].
 

Chemical compound and disease context of Protein Structure, Tertiary

 

Biological context of Protein Structure, Tertiary

 

Anatomical context of Protein Structure, Tertiary

 

Associations of Protein Structure, Tertiary with chemical compounds

 

Gene context of Protein Structure, Tertiary

  • We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin [31].
  • Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly [32].
  • SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor [33].
  • TFIIH is 16 x 12.5 x 7.5 nm in size and is organized into a ring-like structure from which a large protein domain protrudes out [34].
  • The CDK and PCNA inhibitory activities of p21 are shown here to be functionally independent and to reside in separate protein domains [35].
 

Analytical, diagnostic and therapeutic context of Protein Structure, Tertiary

References

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  26. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. Cell (1999) [Pubmed]
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