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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Protein Structure, Tertiary

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Disease relevance of Protein Structure, Tertiary


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High impact information on Protein Structure, Tertiary

  • Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin [7].
  • 1. We identified mutations in a gene encoding a 19-kDa single-transmembrane domain protein, now known as melanocortin 2 receptor accessory protein (MRAP) [8].
  • In contrast, overexpression of placental growth factor, which signals through Flt1 but not kinase insert domain protein receptors (KDRs), had negative effects on neurogenesis and inhibited learning, although it similarly increased endothelial cell proliferation [9].
  • Here, we show that a PS1-dependent gamma-secretase protease activity promotes an epsilon-like cleavage of N-cadherin to produce its intracellular domain peptide, N-Cad/CTF2 [10].
  • Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase [11].

Chemical compound and disease context of Protein Structure, Tertiary


Biological context of Protein Structure, Tertiary


Anatomical context of Protein Structure, Tertiary


Associations of Protein Structure, Tertiary with chemical compounds


Gene context of Protein Structure, Tertiary

  • We find that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin [31].
  • Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly [32].
  • SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor [33].
  • TFIIH is 16 x 12.5 x 7.5 nm in size and is organized into a ring-like structure from which a large protein domain protrudes out [34].
  • The CDK and PCNA inhibitory activities of p21 are shown here to be functionally independent and to reside in separate protein domains [35].

Analytical, diagnostic and therapeutic context of Protein Structure, Tertiary


  1. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Warren, A.J., Colledge, W.H., Carlton, M.B., Evans, M.J., Smith, A.J., Rabbitts, T.H. Cell (1994) [Pubmed]
  2. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Cao, L., Faha, B., Dembski, M., Tsai, L.H., Harlow, E., Dyson, N. Nature (1992) [Pubmed]
  3. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Couillault, C., Pujol, N., Reboul, J., Sabatier, L., Guichou, J.F., Kohara, Y., Ewbank, J.J. Nat. Immunol. (2004) [Pubmed]
  4. LRRK2 in Parkinson's disease: protein domains and functional insights. Mata, I.F., Wedemeyer, W.J., Farrer, M.J., Taylor, J.P., Gallo, K.A. Trends Neurosci. (2006) [Pubmed]
  5. The enzymatic biotinylation of proteins: a post-translational modification of exceptional specificity. Chapman-Smith, A., Cronan, J.E. Trends Biochem. Sci. (1999) [Pubmed]
  6. Purification of a trypsin-type protease from human umbilical vein endothelial cells which is highly sensitive to the Kunitz inhibitor domain peptide of Alzheimer's disease amyloid protein precursor. Kido, H., Takeda, M., Wakabayashi, H., Tanaka, S., Nishimura, N., Takenaka, M., Okada, M. Gerontology. (1993) [Pubmed]
  7. Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin. Otto, E.A., Loeys, B., Khanna, H., Hellemans, J., Sudbrak, R., Fan, S., Muerb, U., O'Toole, J.F., Helou, J., Attanasio, M., Utsch, B., Sayer, J.A., Lillo, C., Jimeno, D., Coucke, P., De Paepe, A., Reinhardt, R., Klages, S., Tsuda, M., Kawakami, I., Kusakabe, T., Omran, H., Imm, A., Tippens, M., Raymond, P.A., Hill, J., Beales, P., He, S., Kispert, A., Margolis, B., Williams, D.S., Swaroop, A., Hildebrandt, F. Nat. Genet. (2005) [Pubmed]
  8. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Metherell, L.A., Chapple, J.P., Cooray, S., David, A., Becker, C., Rüschendorf, F., Naville, D., Begeot, M., Khoo, B., Nürnberg, P., Huebner, A., Cheetham, M.E., Clark, A.J. Nat. Genet. (2005) [Pubmed]
  9. VEGF links hippocampal activity with neurogenesis, learning and memory. Cao, L., Jiao, X., Zuzga, D.S., Liu, Y., Fong, D.M., Young, D., During, M.J. Nat. Genet. (2004) [Pubmed]
  10. A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Marambaud, P., Wen, P.H., Dutt, A., Shioi, J., Takashima, A., Siman, R., Robakis, N.K. Cell (2003) [Pubmed]
  11. Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Zhang, X., Tamaru, H., Khan, S.I., Horton, J.R., Keefe, L.J., Selker, E.U., Cheng, X. Cell (2002) [Pubmed]
  12. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. Stommel, J.M., Marchenko, N.D., Jimenez, G.S., Moll, U.M., Hope, T.J., Wahl, G.M. EMBO J. (1999) [Pubmed]
  13. Molecular mechanisms of autosomal recessive hypercholesterolemia. Wilund, K.R., Yi, M., Campagna, F., Arca, M., Zuliani, G., Fellin, R., Ho, Y.K., Garcia, J.V., Hobbs, H.H., Cohen, J.C. Hum. Mol. Genet. (2002) [Pubmed]
  14. The biotinyl domain of Escherichia coli acetyl-CoA carboxylase. Evidence that the "thumb" structure id essential and that the domain functions as a dimer. Cronan, J.E. J. Biol. Chem. (2001) [Pubmed]
  15. HPr(His approximately P)-mediated phosphorylation differently affects counterflow and proton motive force-driven uptake via the lactose transport protein of Streptococcus thermophilus. Gunnewijk, M.G., Poolman, B. J. Biol. Chem. (2000) [Pubmed]
  16. Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells. El Yazidi-Belkoura, I., Adriaenssens, E., Dollé, L., Descamps, S., Hondermarck, H. J. Biol. Chem. (2003) [Pubmed]
  17. Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. McGinnis, W., Hart, C.P., Gehring, W.J., Ruddle, F.H. Cell (1984) [Pubmed]
  18. Maternal control of embryogenesis by MEDEA, a polycomb group gene in Arabidopsis. Grossniklaus, U., Vielle-Calzada, J.P., Hoeppner, M.A., Gagliano, W.B. Science (1998) [Pubmed]
  19. The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein. Odenwald, W.F., Garbern, J., Arnheiter, H., Tournier-Lasserve, E., Lazzarini, R.A. Genes Dev. (1989) [Pubmed]
  20. Dorsal and neural expression of a tyrosine kinase-related Drosophila gene during embryonic development. Haller, J., Côté, S., Brönner, G., Jäckle, H. Genes Dev. (1987) [Pubmed]
  21. A glycophospholipid anchor is required for Qa-2-mediated T cell activation. Robinson, P.J., Millrain, M., Antoniou, J., Simpson, E., Mellor, A.L. Nature (1989) [Pubmed]
  22. Regulation of Sar1 NH2 terminus by GTP binding and hydrolysis promotes membrane deformation to control COPII vesicle fission. Bielli, A., Haney, C.J., Gabreski, G., Watkins, S.C., Bannykh, S.I., Aridor, M. J. Cell Biol. (2005) [Pubmed]
  23. An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. Otey, C.A., Pavalko, F.M., Burridge, K. J. Cell Biol. (1990) [Pubmed]
  24. Localization and topography of antigenic domains within the heavy chain of smooth muscle myosin. Schneider, M.D., Sellers, J.R., Vahey, M., Preston, Y.A., Adelstein, R.S. J. Cell Biol. (1985) [Pubmed]
  25. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. Hobert, O., Moerman, D.G., Clark, K.A., Beckerle, M.C., Ruvkun, G. J. Cell Biol. (1999) [Pubmed]
  26. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. Cell (1999) [Pubmed]
  27. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A., Poellinger, L. Nature (2001) [Pubmed]
  28. Role of heteromer formation in GABAB receptor function. Kuner, R., Köhr, G., Grünewald, S., Eisenhardt, G., Bach, A., Kornau, H.C. Science (1999) [Pubmed]
  29. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., Valvano, M.A., Foster, S.J., Mak, T.W., Nuñez, G., Inohara, N. Nat. Immunol. (2003) [Pubmed]
  30. The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture. Merckel, M.C., Huiskonen, J.T., Bamford, D.H., Goldman, A., Tuma, R. Mol. Cell (2005) [Pubmed]
  31. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., Chen, Z.J. Cell (2000) [Pubmed]
  32. Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly. Prehoda, K.E., Lee, D.J., Lim, W.A. Cell (1999) [Pubmed]
  33. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Tsukazaki, T., Chiang, T.A., Davison, A.F., Attisano, L., Wrana, J.L. Cell (1998) [Pubmed]
  34. Molecular structure of human TFIIH. Schultz, P., Fribourg, S., Poterszman, A., Mallouh, V., Moras, D., Egly, J.M. Cell (2000) [Pubmed]
  35. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Luo, Y., Hurwitz, J., Massagué, J. Nature (1995) [Pubmed]
  36. Identification of two collagen domains within the bullous pemphigoid autoantigen, BP180. Giudice, G.J., Squiquera, H.L., Elias, P.M., Diaz, L.A. J. Clin. Invest. (1991) [Pubmed]
  37. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Serino, G., Tsuge, T., Kwok, S., Matsui, M., Wei, N., Deng, X.W. Plant Cell (1999) [Pubmed]
  38. Molecular evolution and genetic engineering of protein domains involving aspartate transcarbamoylase. Wild, J.R., Wales, M.E. Annu. Rev. Microbiol. (1990) [Pubmed]
  39. Pax-3 contains domains for transcription activation and transcription inhibition. Chalepakis, G., Jones, F.S., Edelman, G.M., Gruss, P. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  40. Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia. Grimwade, D., Gorman, P., Duprez, E., Howe, K., Langabeer, S., Oliver, F., Walker, H., Culligan, D., Waters, J., Pomfret, M., Goldstone, A., Burnett, A., Freemont, P., Sheer, D., Solomon, E. Blood (1997) [Pubmed]
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