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Gene Review

KCMF1  -  potassium channel modulatory factor 1

Homo sapiens

Synonyms: DEBT91, DKFZP434L1021, E3 ubiquitin-protein ligase KCMF1, FGF-induced in gastric cancer, FIGC, ...
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Disease relevance of KCMF1


High impact information on KCMF1

  • Our data indicate that FIGC upregulation in response to bFGF in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator [1].
  • The FIGC gene was found to encode a polypeptide of 381 amino acids with a novel RING finger module at the NH2-terminus and the COOH-terminal proline-rich region [1].


  1. FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers. Jang, J.H. FEBS Lett. (2004) [Pubmed]
  2. Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing's sarcoma cells. Kreppel, M., Aryee, D.N., Schaefer, K.L., Amann, G., Kofler, R., Poremba, C., Kovar, H. Oncogene (2006) [Pubmed]
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