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MeSH Review

Sarcoma, Ewing's

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Gene context of Sarcoma, Ewing's


Analytical, diagnostic and therapeutic context of Sarcoma, Ewing's




  1. Extracellular matrix-modulated expression of human cell surface glycoproteins A42 and J143. Intrinsic and extrinsic signals determine antigenic phenotype. Rettig, W.J., Murty, V.V., Mattes, M.J., Chaganti, R.S., Old, L.J. J. Exp. Med. (1986) [Pubmed]
  2. Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells. Schweigerer, L., Neufeld, G., Gospodarowicz, D. J. Clin. Invest. (1987) [Pubmed]
  3. c-kit is expressed in soft tissue sarcoma of neuroectodermic origin and its ligand prevents apoptosis of neoplastic cells. Ricotti, E., Fagioli, F., Garelli, E., Linari, C., Crescenzio, N., Horenstein, A.L., Pistamiglio, P., Vai, S., Berger, M., di Montezemolo, L.C., Madon, E., Basso, G. Blood (1998) [Pubmed]
  4. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Zhang, L., Eddy, A., Teng, Y.T., Fritzler, M., Kluppel, M., Melet, F., Bernstein, A. Mol. Cell. Biol. (1995) [Pubmed]
  5. Serum intercellular adhesion molecule-1 in childhood malignancy. Pui, C.H., Luo, X., Evans, W., Martin, S., Rugg, A., Wilimas, J., Crist, W.M., Hudson, M. Blood (1993) [Pubmed]
  6. EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic. May, W.A., Arvand, A., Thompson, A.D., Braun, B.S., Wright, M., Denny, C.T. Nat. Genet. (1997) [Pubmed]
  7. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Sorensen, P.H., Lessnick, S.L., Lopez-Terrada, D., Liu, X.F., Triche, T.J., Denny, C.T. Nat. Genet. (1994) [Pubmed]
  8. Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic. Vlodavsky, I., Lui, G.M., Gospodarowicz, D. Cell (1980) [Pubmed]
  9. Respective roles of laminin and fibronectin in adhesion of human carcinoma and sarcoma cells. Vlodavsky, I., Gospodarowicz, D. Nature (1981) [Pubmed]
  10. Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity. Merchant, M.S., Woo, C.W., Mackall, C.L., Thiele, C.J. J. Natl. Cancer Inst. (2002) [Pubmed]
  11. Influence of doxorubicin dose intensity on response and outcome for patients with osteogenic sarcoma and Ewing's sarcoma. Smith, M.A., Ungerleider, R.S., Horowitz, M.E., Simon, R. J. Natl. Cancer Inst. (1991) [Pubmed]
  12. Taking aim at Ewing's sarcoma: is KIT a target and will imatinib work? Druker, B.J. J. Natl. Cancer Inst. (2002) [Pubmed]
  13. Pretreatment serum lactate dehydrogenase predicting metastatic spread in Ewing's sarcoma. Brereton, H.D., Simon, R., Pomeroy, T.C. Ann. Intern. Med. (1975) [Pubmed]
  14. No benefit of ifosfamide in Ewing's sarcoma: a nonrandomized study of the French Society of Pediatric Oncology. Oberlin, O., Habrand, J.L., Zucker, J.M., Brunat-Mentigny, M., Terrier-Lacombe, M.J., Dubousset, J., Gentet, J.C., Schmitt, C., Ponvert, D., Carrié, C. J. Clin. Oncol. (1992) [Pubmed]
  15. Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors. Mitsiades, N., Poulaki, V., Leone, A., Tsokos, M. J. Natl. Cancer Inst. (1999) [Pubmed]
  16. The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1. May, W.A., Lessnick, S.L., Braun, B.S., Klemsz, M., Lewis, B.C., Lunsford, L.B., Hromas, R., Denny, C.T. Mol. Cell. Biol. (1993) [Pubmed]
  17. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Ichikawa, H., Shimizu, K., Hayashi, Y., Ohki, M. Cancer Res. (1994) [Pubmed]
  18. Differential transactivation by alternative EWS-FLI1 fusion proteins correlates with clinical heterogeneity in Ewing's sarcoma. Lin, P.P., Brody, R.I., Hamelin, A.C., Bradner, J.E., Healey, J.H., Ladanyi, M. Cancer Res. (1999) [Pubmed]
  19. The Ewing's sarcoma gene product functions as a transcriptional activator. Rossow, K.L., Janknecht, R. Cancer Res. (2001) [Pubmed]
  20. Monoclonal antibody identification and characterization of two human sarcoma-associated antigens. Stastny, J.J., Brown, J.M., Beattie, C.W., Das Gupta, T.K. Cancer Res. (1991) [Pubmed]
  21. High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis. Meyers, P.A., Krailo, M.D., Ladanyi, M., Chan, K.W., Sailer, S.L., Dickman, P.S., Baker, D.L., Davis, J.H., Gerbing, R.B., Grovas, A., Herzog, C.E., Lindsley, K.L., Liu-Mares, W., Nachman, J.B., Sieger, L., Wadman, J., Gorlick, R.G. J. Clin. Oncol. (2001) [Pubmed]
  22. Immunomagnetic purging of Ewing's sarcoma from blood and bone marrow: quantitation by real-time polymerase chain reaction. Merino, M.E., Navid, F., Christensen, B.L., Toretsky, J.A., Helman, L.J., Cheung, N.K., Mackall, C.L. J. Clin. Oncol. (2001) [Pubmed]
  23. Experimental evidence for a neural origin of Ewing's sarcoma of bone. Cavazzana, A.O., Miser, J.S., Jefferson, J., Triche, T.J. Am. J. Pathol. (1987) [Pubmed]
  24. The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. Mao, X., Miesfeldt, S., Yang, H., Leiden, J.M., Thompson, C.B. J. Biol. Chem. (1994) [Pubmed]
  25. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Prieur, A., Tirode, F., Cohen, P., Delattre, O. Mol. Cell. Biol. (2004) [Pubmed]
  26. Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines. Barr, F.G., Fitzgerald, J.C., Ginsberg, J.P., Vanella, M.L., Davis, R.J., Bennicelli, J.L. Cancer Res. (1999) [Pubmed]
  27. Ewing's sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5. Mitsiades, N., Poulaki, V., Mitsiades, C., Tsokos, M. Cancer Res. (2001) [Pubmed]
  28. Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway. Spahn, L., Petermann, R., Siligan, C., Schmid, J.A., Aryee, D.N., Kovar, H. Cancer Res. (2002) [Pubmed]
  29. Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics. Kikuta, K., Tochigi, N., Shimoda, T., Yabe, H., Morioka, H., Toyama, Y., Hosono, A., Beppu, Y., Kawai, A., Hirohashi, S., Kondo, T. Clin. Cancer Res. (2009) [Pubmed]
  30. Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma. Merchant, M.S., Yang, X., Melchionda, F., Romero, M., Klein, R., Thiele, C.J., Tsokos, M., Kontny, H.U., Mackall, C.L. Cancer Res. (2004) [Pubmed]
  31. Simultaneous expression of Fas and nonfunctional Fas ligand in Ewing's sarcoma. Kontny, H.U., Lehrnbecher, T.M., Chanock, S.J., Mackall, C.L. Cancer Res. (1998) [Pubmed]
  32. Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Downing, J.R., Khandekar, A., Shurtleff, S.A., Head, D.R., Parham, D.M., Webber, B.L., Pappo, A.S., Hulshof, M.G., Conn, W.P., Shapiro, D.N. Am. J. Pathol. (1995) [Pubmed]
  33. Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma. Lollini, P.L., Palmieri, G., De Giovanni, C., Landuzzi, L., Nicoletti, G., Rossi, I., Griffoni, C., Frabetti, F., Scotlandi, K., Benini, S., Baldini, N., Santoni, A., Nanni, P. Int. J. Cancer (1997) [Pubmed]
  34. In vitro interaction between the N-terminus of the Ewing's sarcoma protein and the subunit of RNA polymerase II hsRPB7. Todorova, R. Mol. Biol. Rep. (2009) [Pubmed]
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