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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DUSP22  -  dual specificity phosphatase 22

Homo sapiens

Synonyms: Dual specificity protein phosphatase 22, JKAP, JNK-stimulatory phosphatase-1, JSP-1, JSP1, ...
 
 
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Disease relevance of DUSP22

  • A C-terminus truncated JSP-1 was expressed in Escherichia coli and was crystallized using the sitting-drop vapor diffusion method [1].
  • In fact, DUSP22 associated with ERalpha in vivo and both endogenous proteins interacted in ERalpha-positive breast cancer T47D cells [2].
 

High impact information on DUSP22

  • Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1 [3].
  • This study illustrates a new aspect of the regulation of MAPK-dependent signal transduction and raises the possibility that JSP-1 may offer a different perspective to the study of various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling [3].
  • In recognition of this relatedness to VHX, we refer to the DUSP15-encoded protein as VH1-related member Y (VHY) [4].
  • VHX expression was not induced by T cell activation, but decreased somewhat at later time points [5].

References

  1. Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution. Yokota, T., Nara, Y., Kashima, A., Matsubara, K., Misawa, S., Kato, R., Sugio, S. Proteins (2007) [Pubmed]
  2. DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118. Sekine, Y., Ikeda, O., Hayakawa, Y., Tsuji, S., Imoto, S., Aoki, N., Sugiyama, K., Matsuda, T. Oncogene (2007) [Pubmed]
  3. Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1. Shen, Y., Luche, R., Wei, B., Gordon, M.L., Diltz, C.D., Tonks, N.K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. Alonso, A., Narisawa, S., Bogetz, J., Tautz, L., Hadzic, R., Huynh, H., Williams, S., Gjörloff-Wingren, A., Bremer, M.C., Holsinger, L.J., Millan, J.L., Mustelin, T. J. Biol. Chem. (2004) [Pubmed]
  5. Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR). Alonso, A., Merlo, J.J., Na, S., Kholod, N., Jaroszewski, L., Kharitonenkov, A., Williams, S., Godzik, A., Posada, J.D., Mustelin, T. J. Biol. Chem. (2002) [Pubmed]
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