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Gene Review

PCNP  -  PEST proteolytic signal containing nuclear...

Homo sapiens

Synonyms: PEST proteolytic signal-containing nuclear protein, PEST-containing nuclear protein
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High impact information on PCNP

  • PCNP was readily ubiquitinated in 293 and COS-7 cells, and NIRF ubiquitinated PCNP in vitro as well as in vivo [1].
  • Considering that NIRF is implicated in cell cycle regulation, these findings suggest that NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, and may constitute a novel signaling pathway with some relation to cell proliferation [1].
  • Furthermore, the NIRF gene is just within small amplicons in some tumors, suggesting that PCNP and NIRF might be involved in some aspects of tumorigenesis [2].


  1. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. Mori, T., Li, Y., Hata, H., Kochi, H. FEBS Lett. (2004) [Pubmed]
  2. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Mori, T., Li, Y., Hata, H., Ono, K., Kochi, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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