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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

VN1R1  -  vomeronasal 1 receptor 1

Homo sapiens

Synonyms: G-protein coupled receptor GPCR24, V1RL1, V1r-like receptor 1, V3r-related gene protein, VNR19I1, ...
 
 
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High impact information on VN1R1

  • The presumed ortholog of V1RL1 was sequenced from 13 species of nonhuman primate, and in eight of these species V1RL1 was a pseudogene [1].
  • V1RL1 has become a pseudogene repeatedly during primate evolution, but patterns of natural selection on primate V1RL genes demonstrate that this gene family diverged under natural selection throughout at least part of primate evolution [2].
 

Biological context of VN1R1

  • Phylogenetic reconstructions reveal that V1RL1 pseudogene formation occurred independently in multiple primate lineages [1].
 

Analytical, diagnostic and therapeutic context of VN1R1

References

  1. Positive selection during the diversification of class I vomeronasal receptor-like (V1RL) genes, putative pheromone receptor genes, in human and primate evolution. Mundy, N.I., Cook, S. Mol. Biol. Evol. (2003) [Pubmed]
  2. Genetic basis of olfactory communication in primates. Mundy, N.I. Am. J. Primatol. (2006) [Pubmed]
  3. Identification of V1R-like putative pheromone receptor sequences in non-human primates. Characterization of V1R pseudogenes in marmoset, a primate species that possesses an intact vomeronasal organ. Giorgi, D., Rouquier, S. Chem. Senses (2002) [Pubmed]
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