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MeSH Review

Selection (Genetics)

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Disease relevance of Selection (Genetics)


High impact information on Selection (Genetics)

  • Evolution of class-I MHC genes and proteins: from natural selection to thymic selection [6].
  • Analysis of genetic variation in a sample of female Australians of Northern European origin showed evidence for Hardy-Weinberg (HW) disequilibrium at polymorphic sites in BRCA1, consistent with the possibility that natural selection is affecting genotype frequencies in modern Europeans [7].
  • Intron size and natural selection [8].
  • This phenomenon provides a selective explanation for the geographical distribution of Thr-Gly lengths and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection [9].
  • Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues [10].

Chemical compound and disease context of Selection (Genetics)


Biological context of Selection (Genetics)


Anatomical context of Selection (Genetics)


Associations of Selection (Genetics) with chemical compounds

  • It appears that in the course of evolution, natural selection has caused the beta-ketoadipate pathway to assume a characteristic set of features or identity in different bacteria [22].
  • These results combine to suggest that balancing natural selection has acted to maintain "taster" and "nontaster" alleles at the PTC locus in humans [16].
  • If this high rate of synthesis represents the requirement of such animals, mutations that caused a loss of ascorbic-acid-synthesizing ability would be eliminated by natural selection on diets that failed to supply these large quantities [23].
  • We have utilized the demographic theory of natural selection developed by Norton and Charlesworth to analyze life history schedules of births and deaths for populations of genotypes in Drosophila pseudoobscura [24].
  • At the molecular level, episodic evolution and positive Darwinian natural selection were apparent within the MHV-H2 S and HE glycoprotein genes [25].

Gene context of Selection (Genetics)


Analytical, diagnostic and therapeutic context of Selection (Genetics)


  1. Transferrin and HLA: spontaneous abortion, neural tube defects, and natural selection. Weitkamp, L.R., Schacter, B.Z. N. Engl. J. Med. (1985) [Pubmed]
  2. Genetic links between brain development and brain evolution. Gilbert, S.L., Dobyns, W.B., Lahn, B.T. Nat. Rev. Genet. (2005) [Pubmed]
  3. On the evolution of accuracy and cost of proofreading tRNA aminoacylation. Savageau, M.A., Freter, R.R. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  4. Selection in context: patterns of natural selection in the glycoprotein 120 region of human immunodeficiency virus 1 within infected individuals. Templeton, A.R., Reichert, R.A., Weisstein, A.E., Yu, X.F., Markham, R.B. Genetics (2004) [Pubmed]
  5. Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae. Hollingshead, S.K., Becker, R., Briles, D.E. Infect. Immun. (2000) [Pubmed]
  6. Evolution of class-I MHC genes and proteins: from natural selection to thymic selection. Lawlor, D.A., Zemmour, J., Ennis, P.D., Parham, P. Annu. Rev. Immunol. (1990) [Pubmed]
  7. Adaptive evolution of the tumour suppressor BRCA1 in humans and chimpanzees. Australian Breast Cancer Family Study. Huttley, G.A., Easteal, S., Southey, M.C., Tesoriero, A., Giles, G.G., McCredie, M.R., Hopper, J.L., Venter, D.J. Nat. Genet. (2000) [Pubmed]
  8. Intron size and natural selection. Carvalho, A.B., Clark, A.G. Nature (1999) [Pubmed]
  9. Natural variation in a Drosophila clock gene and temperature compensation. Sawyer, L.A., Hennessy, J.M., Peixoto, A.A., Rosato, E., Parkinson, H., Costa, R., Kyriacou, C.P. Science (1997) [Pubmed]
  10. Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues. Abi-Rached, L., Parham, P. J. Exp. Med. (2005) [Pubmed]
  11. Lactococcus lactis SpOx spontaneous mutants: a family of oxidative-stress-resistant dairy strains. Rochat, T., Gratadoux, J.J., Corthier, G., Coqueran, B., Nader-Macias, M.E., Gruss, A., Langella, P. Appl. Environ. Microbiol. (2005) [Pubmed]
  12. Design of gene circuitry by natural selection: analysis of the lactose catabolic system in Escherichia coli. Savageau, M.A. Biochem. Soc. Trans. (1999) [Pubmed]
  13. Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins. Královocová, E., Blumauerová, M., Vanĕk, Z. Folia Microbiol. (Praha) (1977) [Pubmed]
  14. Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes. Young, J.A., Wilkinson, D., Bodmer, W.F., Trowsdale, J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  15. Natural selection and molecular evolution in primate PAX9 gene, a major determinant of tooth development. Pereira, T.V., Salzano, F.M., Mostowska, A., Trzeciak, W.H., Ruiz-Linares, A., Chies, J.A., Saavedra, C., Nagamachi, C., Hurtado, A.M., Hill, K., Castro-de-Guerra, D., Silva-Júnior, W.A., Bortolini, M.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  16. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Wooding, S., Kim, U.K., Bamshad, M.J., Larsen, J., Jorde, L.B., Drayna, D. Am. J. Hum. Genet. (2004) [Pubmed]
  17. DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection. Wooding, S.P., Watkins, W.S., Bamshad, M.J., Dunn, D.M., Weiss, R.B., Jorde, L.B. Am. J. Hum. Genet. (2002) [Pubmed]
  18. Functional and physiological consequences of genetic variation at phosphoglucose isomerase: heat shock protein expression is related to enzyme genotype in a montane beetle. Dahlhoff, E.P., Rank, N.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Molecular cloning of cDNA that encode MHC class I molecules from a New World primate (Saguinus oedipus). Natural selection acts at positions that may affect peptide presentation to T cells. Watkins, D.I., Letvin, N.L., Hughes, A.L., Tedder, T.F. J. Immunol. (1990) [Pubmed]
  20. Natural selection of the Pol gene of bovine immunodeficiency virus. Cooper, C.R., Hanson, L.A., Diehl, W.J., Pharr, G.T., Coats, K.S. Virology (1999) [Pubmed]
  21. Chromosome analysis of human preimplantation embryos. Carrera, M., Veiga, A. Croat. Med. J. (1998) [Pubmed]
  22. The beta-ketoadipate pathway and the biology of self-identity. Harwood, C.S., Parales, R.E. Annu. Rev. Microbiol. (1996) [Pubmed]
  23. Further comments on the ascorbic acid requirement. Jukes, T.H. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  24. A demographic approach to selection. Anderson, W.W., Watanabe, T.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  25. Episodic evolution mediates interspecies transfer of a murine coronavirus. Baric, R.S., Yount, B., Hensley, L., Peel, S.A., Chen, W. J. Virol. (1997) [Pubmed]
  26. A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type. Hu, Q., Cool, B.H., Wang, B., Hearn, M.G., Martin, G.M. Hum. Mol. Genet. (2002) [Pubmed]
  27. Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: evidence for positive natural selection. Karn, R.C., Nachman, M.W. Mol. Biol. Evol. (1999) [Pubmed]
  28. Natural selection during functional divergence to LMP7 and proteasome subunit X (PSMB5) following gene duplication. Bos, D.H. J. Mol. Evol. (2005) [Pubmed]
  29. Local adaptation and population differentiation at the interleukin 13 and interleukin 4 loci. Sakagami, T., Witherspoon, D.J., Nakajima, T., Jinnai, N., Wooding, S., Jorde, L.B., Hasegawa, T., Suzuki, E., Gejyo, F., Inoue, I. Genes Immun. (2004) [Pubmed]
  30. Conditional haploinsufficiency of NCF1 (encoding p47(phox)), a signaling gene with a heterozygous phenotype potentially subject to natural selection. Mitchison, N.A., Harbord, M., Hankin, A., Roes, J. Immunol. Lett. (2005) [Pubmed]
  31. Somatic cytogenetic and azoospermia factor gene microdeletion studies in infertile men. Pina-Neto, J.M., Carrara, R.C., Bisinella, R., Mazzucatto, L.F., Martins, M.D., Sartoratto, E., Yamasaki, R. Braz. J. Med. Biol. Res. (2006) [Pubmed]
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