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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TLR7  -  toll-like receptor 7

Macaca mulatta

 
 
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Disease relevance of TLR7

  • Animals vaccinated with HIV Gag protein/Montanide and CpG ODN or the TLR7/8 agonist had higher frequencies of Th1 responses after primary immunization compared to all other vaccine groups [1].
 

High impact information on TLR7

  • NHP were immunized with HIV Gag protein emulsified in Montanide ISA 51, an oil-based adjuvant, with or without a TLR7/8 agonist, a TLR8 agonist, or the TLR9 ligand cytosine phosphate guanosine oligodeoxynucleotides (CpG ODN), and boosted 12 wk later with a replication-defective adenovirus-expressing HIV-Gag (rAD-Gag) [1].

References

  1. Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. Wille-Reece, U., Flynn, B.J., Loré, K., Koup, R.A., Miles, A.P., Saul, A., Kedl, R.M., Mattapallil, J.J., Weiss, W.R., Roederer, M., Seder, R.A. J. Exp. Med. (2006) [Pubmed]
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