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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FOXP3  -  forkhead box P3

Macaca mulatta

 
 
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High impact information on FOXP3

  • Sorted cells with the surface phenotype CD4(+)CD25(+)CD127(low) had higher levels of intracellular FOXP3 and CTLA-4 and, as determined by functional assays, were suppressive, hypoproliferative, and poorly responsive to TCR signaling [1].

References

  1. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. Hartigan-O'connor, D.J., Poon, C., Sinclair, E., McCune, J.M. J. Immunol. Methods (2007) [Pubmed]
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