Gene Review:
Foxp3 - forkhead box P3
Mus musculus
Synonyms:
Forkhead box protein P3, JM2, Scurfin, scurfin, sf
- Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. Cong, Y., Konrad, A., Iqbal, N., Hatton, R.D., Weaver, C.T., Elson, C.O. J. Immunol. (2005)
- Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. Setoguchi, R., Hori, S., Takahashi, T., Sakaguchi, S. J. Exp. Med. (2005)
- Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Bettelli, E., Dastrange, M., Oukka, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells. Dujardin, H.C., Burlen-Defranoux, O., Boucontet, L., Vieira, P., Cumano, A., Bandeira, A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- FOXP3: Of Mice and Men. Ziegler, S.F. Annu. Rev. Immunol. (2006)
- Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow, M.E., Jeffery, E.W., Hjerrild, K.A., Paeper, B., Clark, L.B., Yasayko, S.A., Wilkinson, J.E., Galas, D., Ziegler, S.F., Ramsdell, F. Nat. Genet. (2001)
- Transforming Growth Factor-beta Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms. Li, M.O., Sanjabi, S., Flavell, R.A. Immunity (2006)
- Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Fontenot, J.D., Rasmussen, J.P., Williams, L.M., Dooley, J.L., Farr, A.G., Rudensky, A.Y. Immunity (2005)
- The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Chae, W.J., Henegariu, O., Lee, S.K., Bothwell, A.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- CD4+CD25+ Regulatory T Cells Protect against Injury in an Innate Murine Model of Chronic Kidney Disease. Mahajan, D., Wang, Y., Qin, X., Wang, Y., Zheng, G., Wang, Y.M., Alexander, S.I., Harris, D.C. J. Am. Soc. Nephrol. (2006)
- An essential role for Scurfin in CD4+CD25+ T regulatory cells. Khattri, R., Cox, T., Yasayko, S.A., Ramsdell, F. Nat. Immunol. (2003)
- CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Tai, X., Cowan, M., Feigenbaum, L., Singer, A. Nat. Immunol. (2005)
- A function for interleukin 2 in Foxp3-expressing regulatory T cells. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A., Rudensky, A.Y. Nat. Immunol. (2005)
- Impaired regulatory T cell function in germ-free mice. Ostman, S., Rask, C., Wold, A.E., Hultkrantz, S., Telemo, E. Eur. J. Immunol. (2006)
- Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Luo, X., Yang, H., Kim, I.S., Saint-Hilaire, F., Thomas, D.A., De, B.P., Ozkaynak, E., Muthukumar, T., Hancock, W.W., Crystal, R.G., Suthanthiran, M. Transplantation (2005)
- LAT-mediated signaling in CD4+CD25+ regulatory T cell development. Koonpaew, S., Shen, S., Flowers, L., Zhang, W. J. Exp. Med. (2006)
- Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Wan, Y.Y., Flavell, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire. Ribot, J., Romagnoli, P., van Meerwijk, J.P. J. Immunol. (2006)
- Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Hong, J., Li, N., Zhang, X., Zheng, B., Zhang, J.Z. Proc. Natl. Acad. Sci. U.S.A. (2005)
- The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. Fallarino, F., Grohmann, U., You, S., McGrath, B.C., Cavener, D.R., Vacca, C., Orabona, C., Bianchi, R., Belladonna, M.L., Volpi, C., Santamaria, P., Fioretti, M.C., Puccetti, P. J. Immunol. (2006)
- Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. Offner, H. J. Neurosci. Res. (2004)
- Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. Sharma, S., Yang, S.C., Zhu, L., Reckamp, K., Gardner, B., Baratelli, F., Huang, M., Batra, R.K., Dubinett, S.M. Cancer Res. (2005)
- Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Gillan, V., Devaney, E. Infect. Immun. (2005)
- Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. Chen, W., Jin, W., Hardegen, N., Lei, K.J., Li, L., Marinos, N., McGrady, G., Wahl, S.M. J. Exp. Med. (2003)
- Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. Muthukumarana, P.A., Lyons, G.E., Miura, Y., Thompson, L.H., Watson, T., Green, C.J., Shurey, S., Hess, A.D., Rosengard, B.R., Metcalfe, S.M. Int. Immunopharmacol. (2006)
- Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Chang, X., Chen, L., Wen, J., Godfrey, V.L., Qiao, G., Hussien, Y., Zhang, J., Gao, J.X. Clin. Immunol. (2006)
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. Coombes, J.L., Siddiqui, K.R., Arancibia-Cárcamo, C.V., Hall, J., Sun, C.M., Belkaid, Y., Powrie, F. J. Exp. Med. (2007)
- Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors. Nair, R.E., Kilinc, M.O., Jones, S.A., Egilmez, N.K. J. Immunol. (2006)
- Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. D'Cruz, L.M., Klein, L. Nat. Immunol. (2005)
- Dynamics of CD4+CD25+ T Cells in Spleens and Mesenteric Lymph Nodes of Mice Infected with Schistosoma japonicum. Cai, X.P., Zhang, H., Zhang, Y.C., Wang, Y., Su, C., Ji, M.J., Wu, H.W., Zhu, X., Zhang, Z.S., Wu, G.L. Acta Biochim. Biophys. Sin. (Shanghai) (2006)
- Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. Lee, I., Wang, L., Wells, A.D., Dorf, M.E., Ozkaynak, E., Hancock, W.W. J. Exp. Med. (2005)
- Heme Oxygenase-1-Mediated CD4+CD25high Regulatory T Cells Suppress Allergic Airway Inflammation. Xia, Z.W., Zhong, W.W., Xu, L.Q., Sun, J.L., Shen, Q.X., Wang, J.G., Shao, J., Li, Y.Z., Yu, S.C. J. Immunol. (2006)
- Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. Lin, W., Truong, N., Grossman, W.J., Haribhai, D., Williams, C.B., Wang, J., Martín, M.G., Chatila, T.A. J. Allergy Clin. Immunol. (2005)