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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PLEKHA2  -  pleckstrin homology domain containing,...

Homo sapiens

Synonyms: PH domain-containing family A member 2, Pleckstrin homology domain-containing family A member 2, TAPP-2, TAPP2, Tandem PH domain-containing protein 2
 
 
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High impact information on PLEKHA2

  • In contrast, recruitment specified by the Bam32 or TAPP2 PH domains is completely insensitive to FcgammaRII inhibition [1].
  • Together, these results suggest that Bam32 and TAPP2 adaptors define a novel group of SHIP-activated targets of PI3K that regulate B cell Ag receptor signaling [1].
  • Overexpression of TAPP2 in B cells led to an increase in the sustained phase of the calcium response and increased NF-AT-dependent transcriptional activation after B cell Ag receptor ligation [1].
  • This differential regulation can be accounted for by Src homology 2-containing inositol polyphosphate 5-phosphatase (SHIP) activity alone, as expression of membrane-targeted SHIP completely abrogated Btk recruitment, but had no inhibitory effect on Bam32 or TAPP2 recruitment [1].
 

Associations of PLEKHA2 with chemical compounds

  • Analysis of 3-phosphoinositide generation under activating and inhibitory signaling conditions indicated that recruitment of Bam32 and TAPP2 is inversely correlated with the SHIP substrate/product ratio (phosphatidylinositol 3,4,5-trisphosphate/phosphatidylinositol 3,4-bisphosphate) [1].
  • Peroxide was found to induce dose-dependant membrane recruitment of the PI(3,4)P2-binding PH domain proteins Bam32, TAPP2 and Akt/PKB but not the PIP3-binding PH domain of Btk [2].

References

  1. Two distinct waves of membrane-proximal B cell antigen receptor signaling differentially regulated by Src homology 2-containing inositol polyphosphate 5-phosphatase. Krahn, A.K., Ma, K., Hou, S., Duronio, V., Marshall, A.J. J. Immunol. (2004) [Pubmed]
  2. Regulation of phosphoinositide 3-kinase signaling by oxidants: Hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins. Cheung, S.M., Kornelson, J.C., Al-Alwan, M., Marshall, A.J. Cell. Signal. (2007) [Pubmed]
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