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Chemical Compound Review

PtdIns(3,4)P     [(1S,2S,3S,4R,5R,6S)-3- [[(2R)-2,3...

Synonyms: P6990_SIGMA, CMC_6569, CMC_9576, CMC_11404, AC1LD8BU, ...
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High impact information on dipalmitoylphosphoinositol

  • These responses are highly correlated with temporal and spatial accumulations of PI(3,4,5)P3/PI(3,4)P2 reflected by the translocation of specific PH domains to the membrane [1].
  • Hence formation of PI(3,4)P2 and PIP3 (presumed to be PI(3,4,5)P3) correlates closely with the early events of neutrophil activation [2].
  • CONCLUSION/INTERPRETATION: Our results indicate that SHIP2 plays a negative regulatory role via the 5'-phosphatase activity in insulin signalling, and that PI(3,4,5)P3 rather than PI(3,4)P2 is important for in vivo regulation of insulin-induced Akt activation leading to glycogen synthesis in L6 myotubes [3].
  • Therefore we conclude that PIK1 and 2, possibly through modulation of the levels of PIP3 and PI(3,4)P2, regulate the organization of actin filaments necessary for circular ruffling during macropinocytosis, the extension of pseudopodia and the aggregation of cells into streams, but not the regulation of cell motility [4].
  • Src homology 2-containing 5'-inositol phosphatase 2 (SHIP2) is known to be one of lipid phosphatases converting PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation of insulin signaling with the fundamental impact on the state of insulin resistance [5].

Biological context of dipalmitoylphosphoinositol


Anatomical context of dipalmitoylphosphoinositol

  • Here we use quantitative microscopy to examine the effect of peroxide on PI(3,4)P2-mediated mobilization of signaling proteins in B lymphocytes [6].

Gene context of dipalmitoylphosphoinositol

  • Lpd contains a PH domain that binds specifically to PI(3,4)P2, an asymmetrically localized signal in chemotactic cells [7].


  1. Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Chen, L., Janetopoulos, C., Huang, Y.E., Iijima, M., Borleis, J., Devreotes, P.N. Mol. Biol. Cell (2003) [Pubmed]
  2. Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils. Traynor-Kaplan, A.E., Thompson, B.L., Harris, A.L., Taylor, P., Omann, G.M., Sklar, L.A. J. Biol. Chem. (1989) [Pubmed]
  3. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Sasaoka, T., Hori, H., Wada, T., Ishiki, M., Haruta, T., Ishihara, H., Kobayashi, M. Diabetologia (2001) [Pubmed]
  4. Disruption of Dictyostelium PI3K genes reduces [32P]phosphatidylinositol 3,4 bisphosphate and [32P]phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. Zhou, K., Pandol, S., Bokoch, G., Traynor-Kaplan, A.E. J. Cell. Sci. (1998) [Pubmed]
  5. Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling. Kagawa, S., Sasaoka, T., Yaguchi, S., Ishihara, H., Tsuneki, H., Murakami, S., Fukui, K., Wada, T., Kobayashi, S., Kimura, I., Kobayashi, M. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  6. Regulation of phosphoinositide 3-kinase signaling by oxidants: Hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins. Cheung, S.M., Kornelson, J.C., Al-Alwan, M., Marshall, A.J. Cell. Signal. (2007) [Pubmed]
  7. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Krause, M., Leslie, J.D., Stewart, M., Lafuente, E.M., Valderrama, F., Jagannathan, R., Strasser, G.A., Rubinson, D.A., Liu, H., Way, M., Yaffe, M.B., Boussiotis, V.A., Gertler, F.B. Dev. Cell (2004) [Pubmed]
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