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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

Qtrt1  -  queuine tRNA-ribosyltransferase 1

Mus musculus

Synonyms: 2610028E17Rik, Guanine insertion enzyme, Queuine tRNA-ribosyltransferase, Tgt, Tgut, ...
 
 
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Disease relevance of Qtrt1

 

High impact information on Qtrt1

  • The enzyme tRNA-guanine transglycosylase, which is a key enzyme in biosynthesis of queuosine in tRNA (inserting Q base into tRNA by a transglycosylase reaction), is active in both tumor cells and normal cells [2].

References

  1. Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line. Gündüz, U., Elliott, M.S., Seubert, P.H., Houghton, J.A., Houghton, P.J., Trewyn, R.W., Katze, J.R. Biochim. Biophys. Acta (1992) [Pubmed]
  2. Characterization and analysis of oncofetal tRNA and its possible application for cancer diagnosis and therapy. Nishimura, S., Shindo-Okada, N., Kasai, H., Kuchino, Y., Noguchi, S., Iigo, M., Hoshi, A. Recent Results Cancer Res. (1983) [Pubmed]
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