Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PKD1 - polycystic kidney disease 1 (autosomal...

Canis lupus familiaris

O'Leary, C.A. et al., Dackowski, W.R. et al.

O'Leary, Atwell, Laing,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PKD1

The aim of this study was to identify possible disease-associated mutations in the canine homologue of the polycystic kidney disease gene 1 (PKD1) in Bull Terriers with autosomal dominant polycystic kidney disease [1].

High impact information on PKD1

Intron 21 of dog PKD1 lacked the polypyrimidine tract characteristic of the human gene, whereas pyrimidine-rich elements were identified in canine intron 30 [2].

References

No disease-associated mutations found in the coding sequence of the canine polycystic kidney disease gene 1 in Bull Terriers with polycystic kidney disease. O'Leary, C.A., Atwell, R.B., Laing, N.G. Anim. Genet. (2003) [Pubmed]
Canine PKD1 is a single-copy gene: genomic organization and comparative analysis. Dackowski, W.R., Luderer, H.F., Manavalan, P., Bukanov, N.O., Russo, R.J., Roberts, B.L., Klinger, K.W., Ibraghimov-Beskrovnaya, O. Genomics (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg