Disease relevance of diiodomethanesulfonic acid

• Intron mobility in the T-even phages has been demonstrated [1].
• Intron 22 inversions and haemophilia [2].
• Intron-size constraint as a mutational mechanism in Rothmund-Thomson syndrome [3].
• Intron insertion facilitates amplification of cloned virus cDNA in Escherichia coli while biological activity is reestablished after transcription in vivo [4].
• Sixty-four patients with hairy-cell leukemia (HCL) (61 had undergone prior splenectomy) were treated with alpha-2 interferon (Intron A, Schering Corp, Kenilworth, NJ) subcutaneously three times per week at a dosage of 2 X 10(6) U/m2 [5].

Psychiatry related information on diiodomethanesulfonic acid

• Intron 2 (T/C) CYP46 Polymorphism Is Associated with Alzheimer's Disease in Chinese Patients [6].
• In Hispanics, current PI antiretroviral therapy (ART) exposure was associated with a significantly smaller increase in TGs among patients with variant alleles at apoC-III-482, -455, and Intron 1, or at a composite apoC-III genotype, compared with patients with the wild-type genotypes [7].

High impact information on diiodomethanesulfonic acid

• Intron overaccumulation could lead to spliced exon reopening via a reaction known to be catalyzed by group I introns in vitro [8].
• Intron 4, located 600 bases from the polyadenylation site, is excised cotranscriptionally in 5%-10% of the molecules and after or during release to the nucleoplasm in the remaining molecules [9].
• Intron within the large rRNA gene of N. crassa mitochondria: a long open reading frame and a consensus sequence possibly important in splicing [10].
• Intron size and natural selection [11].
• Intron excision is an essential step in eukaryotic gene expression, but the molecular mechanisms by which the spliceosome accurately identifies splice sites in nuclear precursors to messenger RNAs (pre-mRNAs) are not well understood [12].

Chemical compound and disease context of diiodomethanesulfonic acid

• Because of the improved clinical benefits, it is anticipated that the PEG Intron plus ribavirin combination therapy will become the new standard of care for the treatment of chronic hepatitis C [13].
• Twenty-two patients with non-Hodgkin's lymphoma (NHL) were treated with a combined regimen of interferon alfa-2b (Intron A; Schering-Plough) and chlorambucil to evaluate the response and efficacy in pre-treated or relapsed patients [14].
• Three exogenous proteins, the LRR domain of internalin B, the T4 lysozyme, and the Intron 8 gene product of the of the HER2 tyrosine kinase receptor were derivatized with appropriate bifunctional cross-linkers and conjugated to the virus capsid [15].
• We have tested the ability of interferon alfa-2b (Intron A; Schering-Plough) to prolong remissions induced by busulfan in patients with chronic granulocytic leukemia (CGL) [16].
• Intron 9 contains the complete endogenous retrovirus HERV-K(C4) as a 6.4-kb insertion in 60% of human C4 genes [17].

Biological context of diiodomethanesulfonic acid

• Intron 4 (14) of the split gene cob in mitochondrial DNA contains a long open reading frame in phase with the preceding exon [18].
• Intron 1 was also shown to contain a left side-specific enhancer (ASE) that was able to direct transgene expression in the lateral plate mesoderm and prospective floor plate on the left side [19].
• Intron mobility in phage T4 occurs in the context of recombination-dependent DNA replication by way of multiple pathways [20].
• The Receptor for Branch-Site Docking within a Group II Intron Active Site [21].
• Intron phylogeny: a new hypothesis [22].

Anatomical context of diiodomethanesulfonic acid

• Intron-containing pre-tRNAs from organisms as different as yeast, Nicotiana, Xenopus and man are efficiently spliced and processed in a HeLa cell extract [23].
• Intron-containing expression cassettes were transfected into a human cell line, and RNA transcripts were analyzed for intron removal [24].
• Intron 1 enhancer activity alone is therefore insufficient to account for the discrepancy between endogenous transcript levels and core muscle promoter activity in immature and mature skeletal muscle and points to the existence of additional enhancer elements in other regions of the DMD gene [25].
• A larger transcript containing Intron II was present in both cancers and normal mucosa but was barely discernible in the gastric antrum [26].
• Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway [27].

Associations of diiodomethanesulfonic acid with other chemical compounds

• Structural aspects of the human C5 gene. Intron/exon organization, 5'-flanking region features, and characterization of two truncated cDNA clones [28].
• The efficacy of Ampligen was compared with that of the interferon inducer poly(inosinic acid)-poly(cytidylic acid) [poly(IC)], alpha interferon 2b (INTRON A), and pegylated alpha interferon 2b (PEG-INTRON-alpha-2b) [29].
• We now report that a combination of recombinant interferon alpha (Intron; Schering) and retinoic acid is synergistically cytostatic for HL-60 cells [30].
• The regimen studied consisted of 5-fluorouracil, 750 mg/M2/day, by continuous intravenous infusion on Days 1-5, and interferon-alpha-2b (Intron A), 5 x 10(6)U/M2/day, subcutaneously on Days 1, 3, and 5, repeated every 21 days [31].
• Response, assessed based on viral load and liver enzymes, was compared to that of 27 patients (group B) who received Intron A 3 million units 3 times weekly and daily Ribavirin (same dose) for 12 months (standard regimen) [32].

Gene context of diiodomethanesulfonic acid

• Intron positions are also fairly well conserved among KNAT1, KNAT2, and kn1 [33].
• Intron mutations affect splicing of Saccharomyces cerevisiae SUP53 precursor tRNA [34].
• Intron-containing, immature hTERT RNA was observed only in nuclei of telomerase-positive cells, which suggests that hTERT RNA levels are transcriptionally regulated [35].
• Intron 2 of Scn8a is flanked by minor class AT-AC splice sites [36].
• Intron 6 of xTFIIS.oA contains splice and branch site consensus sequences conforming to those of the minor class of AT-AC introns and this was confirmed for the homeologous xTFIIS.oB gene by genomic PCR [37].

Analytical, diagnostic and therapeutic context of diiodomethanesulfonic acid

• Intron degradation and exon ligation only occur in double mutants with restored base pairing between the gamma and gamma' sites [38].
• The Sunbelt Melanoma Trial examines the therapeutic value of completion dissection and benefits of Intron A [39].
• Since interferon alfa-2b (Intron A) is useful as a single agent, it is important to determine if interferon can be combined with standard chemotherapy to improve both response and survival in patients with cancer [40].
• BLAST search of the NCBI mouse EST database and RT-PCR analysis uncovered two differentially spliced transcripts, "mcal-A" and "mcal-B." The two transcripts are identical, except that mcal-B contains a longer 3' untranslated region due to retention of a short intron (I5) between exons five and six [41].
• This multicenter study reports on 128 patients with hairy cell leukemia (HCL) who were treated subcutaneously with alfa-2b interferon (Intron A, Schering Corp, Kenilworth, NJ), three times a week at a dosage of 2 megaunits/m2 [42].

References