Gene Review:
Pkd1 - polycystic kidney disease 1 homolog
Mus musculus
Synonyms:
Autosomal dominant polycystic kidney disease 1 protein homolog, PC-1, PC1, Polycystin-1, mFLJ00285, ...
- Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease. Wu, G., Tian, X., Nishimura, S., Markowitz, G.S., D'Agati, V., Park, J.H., Yao, L., Li, L., Geng, L., Zhao, H., Edelmann, W., Somlo, S. Hum. Mol. Genet. (2002)
- A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. Piontek, K.B., Huso, D.L., Grinberg, A., Liu, L., Bedja, D., Zhao, H., Gabrielson, K., Qian, F., Mei, C., Westphal, H., Germino, G.G. J. Am. Soc. Nephrol. (2004)
- Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney. Ward, C.J., Turley, H., Ong, A.C., Comley, M., Biddolph, S., Chetty, R., Ratcliffe, P.J., Gattner, K., Harris, P.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- The polycystin 1-C-terminal fragment stimulates ERK-dependent spreading of renal epithelial cells. Joly, D., Ishibe, S., Nickel, C., Yu, Z., Somlo, S., Cantley, L.G. J. Biol. Chem. (2006)
- Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes. Lu, W., Fan, X., Basora, N., Babakhanlou, H., Law, T., Rifai, N., Harris, P.C., Perez-Atayde, A.R., Rennke, H.G., Zhou, J. Nat. Genet. (1999)
- Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Lu, W., Peissel, B., Babakhanlou, H., Pavlova, A., Geng, L., Fan, X., Larson, C., Brent, G., Zhou, J. Nat. Genet. (1997)
- Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. Chauvet, V., Tian, X., Husson, H., Grimm, D.H., Wang, T., Hiesberger, T., Hieseberger, T., Igarashi, P., Bennett, A.M., Ibraghimov-Beskrovnaya, O., Somlo, S., Caplan, M.J. J. Clin. Invest. (2004)
- The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. Nickel, C., Benzing, T., Sellin, L., Gerke, P., Karihaloo, A., Liu, Z.X., Cantley, L.G., Walz, G. J. Clin. Invest. (2002)
- Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Boulter, C., Mulroy, S., Webb, S., Fleming, S., Brindle, K., Sandford, R. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression. Xiao, Z., Zhang, S., Mahlios, J., Zhou, G., Magenheimer, B.S., Guo, D., Dallas, S.L., Maser, R., Calvet, J.P., Bonewald, L., Quarles, L.D. J. Biol. Chem. (2006)
- More than colocalizing with polycystin-1, polycystin-L is in the centrosome. Bui-Xuan, E.F., Li, Q., Chen, X.Z., Boucher, C.A., Sandford, R., Zhou, J., Basora, N. Am. J. Physiol. Renal Physiol. (2006)
- Functional analysis of PKD1 transgenic lines reveals a direct role for polycystin-1 in mediating cell-cell adhesion. Streets, A.J., Newby, L.J., O'Hare, M.J., Bukanov, N.O., Ibraghimov-Beskrovnaya, O., Ong, A.C. J. Am. Soc. Nephrol. (2003)
- Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. Newby, L.J., Streets, A.J., Zhao, Y., Harris, P.C., Ward, C.J., Ong, A.C. J. Biol. Chem. (2002)
- Murine Pkd1 is a developmentally regulated gene from morula to adulthood: role in tissue condensation and patterning. Guillaume, R., D'Agati, V., Daoust, M., Trudel, M. Dev. Dyn. (1999)
- Autosomal dominant polycystic kidney disease: clues to pathogenesis. Harris, P.C. Hum. Mol. Genet. (1999)
- Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. Hughes, J., Ward, C.J., Aspinwall, R., Butler, R., Harris, P.C. Hum. Mol. Genet. (1999)
- Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. Yamaguchi, T., Wallace, D.P., Magenheimer, B.S., Hempson, S.J., Grantham, J.J., Calvet, J.P. J. Biol. Chem. (2004)
- Polycystin: new aspects of structure, function, and regulation. Wilson, P.D. J. Am. Soc. Nephrol. (2001)
- Polycystin-1L2 is a novel G-protein-binding protein. Yuasa, T., Takakura, A., Denker, B.M., Venugopal, B., Zhou, J. Genomics (2004)
- Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. Guay-Woodford, L.M., Wright, C.J., Walz, G., Churchill, G.A. J. Am. Soc. Nephrol. (2000)
- Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. Grimm, D.H., Cai, Y., Chauvet, V., Rajendran, V., Zeltner, R., Geng, L., Avner, E.D., Sweeney, W., Somlo, S., Caplan, M.J. J. Biol. Chem. (2003)
- The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Shillingford, J.M., Murcia, N.S., Larson, C.H., Low, S.H., Hedgepeth, R., Brown, N., Flask, C.A., Novick, A.C., Goldfarb, D.A., Kramer-Zucker, A., Walz, G., Piontek, K.B., Germino, G.G., Weimbs, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Stayner, C., Iglesias, D.M., Goodyer, P.R., Ellis, L., Germino, G., Zhou, J., Eccles, M.R. Hum. Mol. Genet. (2006)
- Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice. Sharma, M., Brantley, J.G., Alcalay, N.I., Zhou, J., Heystek, E., Maser, R.L., Vanden Heuvel, G.B. Kidney Int. (2005)
- Analysis of the polycystins in aortic vascular smooth muscle cells. Qian, Q., Li, M., Cai, Y., Ward, C.J., Somlo, S., Harris, P.C., Torres, V.E. J. Am. Soc. Nephrol. (2003)
- Expression of polycystin in mouse metanephros and extra-metanephric tissues. Griffin, M.D., O'Sullivan, D.A., Torres, V.E., Grande, J.P., Kanwar, Y.S., Kumar, R. Kidney Int. (1997)