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Gene Review

ZAN  -  zonadhesin

Macaca mulatta

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High impact information on ZAN

  • To elucidate the evolution of proteins involved in human reproduction, we studied the sequence evolution of MAM domains of the sperm-ligand zonadhesin in respect to single amino acid sites, solvent accessibility, and posttranslational modification [1].

Biological context of ZAN

  • We conclude that the binding specificity of zonadhesin MAM domains, especially of the presumed epitope, is achieved by positive selection at the level of single amino acid sites and posttranslational modifications, respectively [1].


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