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Gene Review

ZAN  -  zonadhesin (gene/pseudogene)

Homo sapiens

Synonyms: Zonadhesin
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Disease relevance of ZAN


High impact information on ZAN


Biological context of ZAN


Anatomical context of ZAN

  • Subsequent redistribution of zonadhesin resulted in its elimination from the inner acrosomal membrane and restriction to the outer acrosomal membrane of the apical and principal segments and the contents of the posterior acrosome [4].
  • In this study of hamster spermatozoa, we demonstrate that zonadhesin does not localize to the sperm surface but is instead a constituent of the acrosomal matrix [4].
  • In round spermatids, zonadhesin localized specifically to the acrosomal membrane, where it appeared to be evenly distributed between the outer and inner membrane domains [4].
  • These data suggest an important structural role for zonadhesin in assembly of the acrosomal matrix and further support the view that the species specificity of zona pellucida adhesion is mediated by egg-binding proteins contained within the acrosome rather than on the periacrosomal plasma membrane [4].

Associations of ZAN with chemical compounds

  • The mutation results in the replacement of a cysteine in one of the repeats of the zonadhesin/Von Willebrand domain of the protein and might cause a change in the crosslinking of the polypeptide [6].

Other interactions of ZAN


Analytical, diagnostic and therapeutic context of ZAN

  • From Jaeger (1) a Masterlab bodyplethysmograph, (2) a Pneumoscreen pneumotachograph, (3) a Masterscreen CS-FRC and (4) a Masterlab CompactTransfer (the latter two measure the diffusion capacity) were compared, and from ZAN a bodyplethysmograph system encompassing spirometry, flow-volume curve and diffusion capacity measurements [8].
  • Immunoelectron microscopy revealed that distinct targeting pathways during spermiogenesis and sperm maturation in the epididymis result in trafficking of zonadhesin to the acrosomal matrix [4].


  1. Mutation in the zonadhesin-like domain of alpha-tectorin associated with autosomal dominant non-syndromic hearing loss. Alloisio, N., Morlé, L., Bozon, M., Godet, J., Verhoeven, K., Van Camp, G., Plauchu, H., Muller, P., Collet, L., Lina-Granade, G. Eur. J. Hum. Genet. (1999) [Pubmed]
  2. Molecular population genetics of the gene encoding the human fertilization protein zonadhesin reveals rapid adaptive evolution. Gasper, J., Swanson, W.J. Am. J. Hum. Genet. (2006) [Pubmed]
  3. Tandem repetitive d domains of the sperm ligand zonadhesin evolve faster in the paralogue than in the orthologue comparison. Herlyn, H., Zischler, H. J. Mol. Evol. (2006) [Pubmed]
  4. Zonadhesin assembly into the hamster sperm acrosomal matrix occurs by distinct targeting strategies during spermiogenesis and maturation in the epididymis. Olson, G.E., Winfrey, V.P., Bi, M., Hardy, D.M., NagDas, S.K. Biol. Reprod. (2004) [Pubmed]
  5. Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN). Gao, Z., Harumi, T., Garbers, D.L. Genomics (1997) [Pubmed]
  6. Alpha-tectorin involvement in hearing disabilities: one gene--two phenotypes. Balciuniene, J., Dahl, N., Jalonen, P., Verhoeven, K., Van Camp, G., Borg, E., Pettersson, U., Jazin, E.E. Hum. Genet. (1999) [Pubmed]
  7. Sperm adhesion molecules: structure and function. Jansen, S., Ekhlasi-Hundrieser, M., Töpfer-Petersen, E. Cells Tissues Organs (Print) (2001) [Pubmed]
  8. A comparison of lung function equipment with emphasis on interchangeability and methods. Munnik, P., Zanen, P., Lammers, J.W. Physiological measurement. (2006) [Pubmed]
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