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Gene Review

D4Mit278  -  DNA segment, Chr 4, Massachusetts...

Mus musculus

 
 
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Disease relevance of D4Mit278

  • In male NZO x F1 backcross mice, a major susceptibility locus for the development of hyperglycemia and hypoinsulinemia (Nidd/SJL) was identified on chromosome 4 between the markers D4Mit278 and D4Mit232, 10-28 cM distal of the previously described Nidd1 locus [1].
 

High impact information on D4Mit278

  • The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination [2].

References

  1. Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of a susceptibility locus on chromosome 4 and its relation with obesity. Plum, L., Kluge, R., Giesen, K., Altmüller, J., Ortlepp, J.R., Joost, H.G. Diabetes (2000) [Pubmed]
  2. Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Maeda, Y.Y., Funata, N., Takahama, S., Sugata, Y., Yonekawa, H. Mamm. Genome (2001) [Pubmed]
 
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