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Disease relevance of Hyperglycemia


Psychiatry related information on Hyperglycemia


High impact information on Hyperglycemia

  • Here we show that mice that lack PDK1 specifically in pancreatic beta cells (betaPdk1(-/-) mice) develop progressive hyperglycemia as a result of a loss of islet mass [11].
  • GLK-deficient mice die perinatally with severe hyperglycemia [12].
  • The affected subjects with glucokinase mutations usually had mild hyperglycemia that began during childhood, whereas in subjects with maturity-onset diabetes of the young not due to glucokinase mutations, hyperglycemia usually appeared after puberty [13].
  • We conclude that patients with Type I diabetes have an acquired defect in interleukin-2 production, whereas patients with Type II diabetes do not, and that this defect is not correlated with an ongoing autoimmune process, with hyperglycemia, or with insulin administration or oral hypoglycemic therapy [14].
  • The hyperglycemia was due mainly to a marked stimulation of hepatic glucose production that occurred without changes in levels of free insulin or glucagon [15].

Chemical compound and disease context of Hyperglycemia


Biological context of Hyperglycemia


Anatomical context of Hyperglycemia


Gene context of Hyperglycemia


Analytical, diagnostic and therapeutic context of Hyperglycemia


  1. Angptl3 regulates lipid metabolism in mice. Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., Furukawa, H. Nat. Genet. (2002) [Pubmed]
  2. Effects of diabetes mellitus on cholesterol metabolism in man. Bennion, L.J., Grundy, S.M. N. Engl. J. Med. (1977) [Pubmed]
  3. Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus. Krolewski, A.S., Laffel, L.M., Krolewski, M., Quinn, M., Warram, J.H. N. Engl. J. Med. (1995) [Pubmed]
  4. Diabetic polyneuropathy: the importance of insulin deficiency, hyperglycemia and alterations in myoinositol metabolism in its pathogenesis. Winegrad, A.I., Greene, D.A. N. Engl. J. Med. (1976) [Pubmed]
  5. Treatment of insulin reactions in diabetics. Brodows, R.G., Williams, C., Amatruda, J.M. JAMA (1984) [Pubmed]
  6. The prevalence of erectile dysfunction in the primary care setting: importance of risk factors for diabetes and vascular disease. Grover, S.A., Lowensteyn, I., Kaouache, M., Marchand, S., Coupal, L., DeCarolis, E., Zoccoli, J., Defoy, I. Arch. Intern. Med. (2006) [Pubmed]
  7. Effects of short-term insulin therapy upon therapeutic response to glipizide. Schwartz, S.L., Fischer, J.S., Kipnes, M.S., Boyle, M. Am. J. Med. (1987) [Pubmed]
  8. Acute and chronic effects of aspirin toxicity and their treatment. Temple, A.R. Arch. Intern. Med. (1981) [Pubmed]
  9. Effect of hyperglycemia on pain threshold in alloxan-diabetic rats. Lee, J.H., Cox, D.J., Mook, D.G., McCarty, R.C. Pain (1990) [Pubmed]
  10. Reduction of rapid eye movement (REM) sleep by glucose alone or glucose and insulin in rats. Sangiah, S., Caldwell, D.F. Life Sci. (1988) [Pubmed]
  11. Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, K.C., Herrera, P.L., Noda, T., Kasuga, M. Nat. Genet. (2006) [Pubmed]
  12. Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Grupe, A., Hultgren, B., Ryan, A., Ma, Y.H., Bauer, M., Stewart, T.A. Cell (1995) [Pubmed]
  13. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. Froguel, P., Zouali, H., Vionnet, N., Velho, G., Vaxillaire, M., Sun, F., Lesage, S., Stoffel, M., Takeda, J., Passa, P. N. Engl. J. Med. (1993) [Pubmed]
  14. Acquired defect in interleukin-2 production in patients with type I diabetes mellitus. Kaye, W.A., Adri, M.N., Soeldner, J.S., Rabinowe, S.L., Kaldany, A., Kahn, C.R., Bistrian, B., Srikanta, S., Ganda, O.P., Eisenbarth, G.S. N. Engl. J. Med. (1986) [Pubmed]
  15. Importance of raised growth hormone levels in mediating the metabolic derangements of diabetes. Press, M., Tamborlane, W.V., Sherwin, R.S. N. Engl. J. Med. (1984) [Pubmed]
  16. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. Mitrakou, A., Kelley, D., Mokan, M., Veneman, T., Pangburn, T., Reilly, J., Gerich, J. N. Engl. J. Med. (1992) [Pubmed]
  17. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperlipoproteinemia. Stacpoole, P.W., Moore, G.W., Kornhauser, D.M. N. Engl. J. Med. (1978) [Pubmed]
  18. Dexamethasone in the treatment of acute mountain sickness. Levine, B.D., Yoshimura, K., Kobayashi, T., Fukushima, M., Shibamoto, T., Ueda, G. N. Engl. J. Med. (1989) [Pubmed]
  19. Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. Bantle, J.P., Laine, D.C., Castle, G.W., Thomas, J.W., Hoogwerf, B.J., Goetz, F.C. N. Engl. J. Med. (1983) [Pubmed]
  20. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Berg, A.H., Combs, T.P., Du, X., Brownlee, M., Scherer, P.E. Nat. Med. (2001) [Pubmed]
  21. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. Gyurko, R., Siqueira, C.C., Caldon, N., Gao, L., Kantarci, A., Van Dyke, T.E. J. Immunol. (2006) [Pubmed]
  22. Effect of sustained-mild and transient-severe hyperglycemia on ischemia-induced blood-brain barrier opening. Ennis, S.R., Keep, R.F. J. Cereb. Blood Flow Metab. (2007) [Pubmed]
  23. Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes. Novak, B.J., Blake, D.R., Meinardi, S., Rowland, F.S., Pontello, A., Cooper, D.M., Galassetti, P.R. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  24. Mechanism and management of AKT inhibitor-induced hyperglycemia. Crouthamel, M.C., Kahana, J.A., Korenchuk, S., Zhang, S.Y., Sundaresan, G., Eberwein, D.J., Brown, K.K., Kumar, R. Clin. Cancer Res. (2009) [Pubmed]
  25. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Bernal-Mizrachi, C., Weng, S., Feng, C., Finck, B.N., Knutsen, R.H., Leone, T.C., Coleman, T., Mecham, R.P., Kelly, D.P., Semenkovich, C.F. Nat. Med. (2003) [Pubmed]
  26. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Ferber, S., Halkin, A., Cohen, H., Ber, I., Einav, Y., Goldberg, I., Barshack, I., Seijffers, R., Kopolovic, J., Kaiser, N., Karasik, A. Nat. Med. (2000) [Pubmed]
  27. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Lewis, G.F., Carpentier, A., Adeli, K., Giacca, A. Endocr. Rev. (2002) [Pubmed]
  28. Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects. Bogardus, C., Lillioja, S., Howard, B.V., Reaven, G., Mott, D. J. Clin. Invest. (1984) [Pubmed]
  29. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. Igarashi, M., Wakasaki, H., Takahara, N., Ishii, H., Jiang, Z.Y., Yamauchi, T., Kuboki, K., Meier, M., Rhodes, C.J., King, G.L. J. Clin. Invest. (1999) [Pubmed]
  30. Blood-brain glucose transfer: repression in chronic hyperglycemia. Gjedde, A., Crone, C. Science (1981) [Pubmed]
  31. Pentamidine-associated fatal acute pancreatitis. Zuger, A., Wolf, B.Z., el-Sadr, W., Simberkoff, M.S., Rahal, J.J. JAMA (1986) [Pubmed]
  32. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. Leahy, J.L., Cooper, H.E., Deal, D.A., Weir, G.C. J. Clin. Invest. (1986) [Pubmed]
  33. Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists. Elias, D., Rapoport, M., Cohen, I.R., Shechter, Y. J. Clin. Invest. (1988) [Pubmed]
  34. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Uchida, T., Nakamura, T., Hashimoto, N., Matsuda, T., Kotani, K., Sakaue, H., Kido, Y., Hayashi, Y., Nakayama, K.I., White, M.F., Kasuga, M. Nat. Med. (2005) [Pubmed]
  35. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Laustsen, P.G., Michael, M.D., Crute, B.E., Cohen, S.E., Ueki, K., Kulkarni, R.N., Keller, S.R., Lienhard, G.E., Kahn, C.R. Genes Dev. (2002) [Pubmed]
  36. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A.A., Kahn, C.R., Ntambi, J.M., Socci, N.D., Friedman, J.M. J. Clin. Invest. (2004) [Pubmed]
  37. Altered aldose reductase gene regulation in cultured human retinal pigment epithelial cells. Henry, D.N., Del Monte, M., Greene, D.A., Killen, P.D. J. Clin. Invest. (1993) [Pubmed]
  38. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. Xu, A., Wang, Y., Keshaw, H., Xu, L.Y., Lam, K.S., Cooper, G.J. J. Clin. Invest. (2003) [Pubmed]
  39. Glucagon: role in the hyperglycemia of diabetes mellitus. Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., Unger, R. Science (1975) [Pubmed]
  40. Effect of glycemic control on early diabetic renal lesions. A 5-year randomized controlled clinical trial of insulin-dependent diabetic kidney transplant recipients. Barbosa, J., Steffes, M.W., Sutherland, D.E., Connett, J.E., Rao, K.V., Mauer, S.M. JAMA (1994) [Pubmed]
  41. Large scale isolation, growth, and function of porcine neonatal islet cells. Korbutt, G.S., Elliott, J.F., Ao, Z., Smith, D.K., Warnock, G.L., Rajotte, R.V. J. Clin. Invest. (1996) [Pubmed]
  42. Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans. Schirra, J., Sturm, K., Leicht, P., Arnold, R., Göke, B., Katschinski, M. J. Clin. Invest. (1998) [Pubmed]
  43. Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. Giaccari, A., Rossetti, L. J. Clin. Invest. (1992) [Pubmed]
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