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Gene Review

NEUROD6  -  neuronal differentiation 6

Homo sapiens

Synonyms: ATOH2, Atoh2, BHLHA2, Class A basic helix-loop-helix protein 2, MATH2, ...
 
 
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High impact information on NEUROD6

  • This was concurrent with increased transcription of immediate-early genes linked to differentiation such as cdk-5 and NeuroD6, and activity of AP-1 transcription family members such as c-fos, fos-B, and jun-D [1].
  • 5'UTR of the neurogenic bHLH Nex1/MATH-2/NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites [2].
  • GATA-3 expression, on the other hand, was detected only in advanced stages of the neuronal maturation, which were characterised by the activation of the Math2 neuronal gene [3].

References

  1. The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. Cavaliere, F., Nestola, V., Amadio, S., D'Ambrosi, N., Angelini, D.F., Sancesario, G., Bernardi, G., Volonté, C. Neurobiol. Dis. (2005) [Pubmed]
  2. 5'UTR of the neurogenic bHLH Nex1/MATH-2/NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites. Uittenbogaard, M., Martinka, D.L., Johnson, P.F., Vinson, C., Chiaramello, A. J. Neurosci. Res. (2007) [Pubmed]
  3. SCL, GATA-2 and Lmo2 expression in neurogenesis. Herberth, B., Minkó, K., Csillag, A., Jaffredo, T., Madarász, E. Int. J. Dev. Neurosci. (2005) [Pubmed]
 
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