Gene Review:
SNHG6 - small nucleolar RNA host gene 6 (non...
Homo sapiens
Synonyms:
HBII-276HG, NCRNA00058, U87HG
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High impact information on SNHG6
- Unlike transcripts of four other known non-protein-coding host genes, U87HG RNA shows a relatively high degree of conservation suggesting a selective pressure and a possible functional activity of U87HG apart from producing U87 snoRNA [1].
- Noncoding RNA of U87 host gene is associated with ribosomes and is relatively resistant to nonsense-mediated decay [1].
- U87HG RNA carried multiple stop-codons and was associated with ribosomes, suggesting that it may be a target for nonsense-mediated mRNA decay (NMD), a process that eliminates transcripts bearing nonsense mutations [1].
- While most snoRNA genes reside in introns of protein-coding genes, here we demonstrated an unusual snoRNA gene occupying an intron of a previously unknown non-protein-coding gene U87HG [1].
References
- Noncoding RNA of U87 host gene is associated with ribosomes and is relatively resistant to nonsense-mediated decay. Makarova, J.A., Kramerov, D.A. Gene (2005) [Pubmed]
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