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Gene Review

SNHG6  -  small nucleolar RNA host gene 6 (non...

Homo sapiens

Synonyms: HBII-276HG, NCRNA00058, U87HG
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High impact information on SNHG6

  • Unlike transcripts of four other known non-protein-coding host genes, U87HG RNA shows a relatively high degree of conservation suggesting a selective pressure and a possible functional activity of U87HG apart from producing U87 snoRNA [1].
  • Noncoding RNA of U87 host gene is associated with ribosomes and is relatively resistant to nonsense-mediated decay [1].
  • U87HG RNA carried multiple stop-codons and was associated with ribosomes, suggesting that it may be a target for nonsense-mediated mRNA decay (NMD), a process that eliminates transcripts bearing nonsense mutations [1].
  • While most snoRNA genes reside in introns of protein-coding genes, here we demonstrated an unusual snoRNA gene occupying an intron of a previously unknown non-protein-coding gene U87HG [1].


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