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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GAREM  -  GRB2 associated, regulator of MAPK1

Homo sapiens

Synonyms: C18orf11, FAM59A, FLJ21610, GRB2-associated and regulator of MAPK protein, GRB2-associated and regulator of MAPK1, ...
 
 
 
 
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Regulatory relationships of FAM59A

  • Erk activation in response to EGF stimulation is regulated by the expression of GAREM in COS-7 and HeLa cells, which occurs independent of the presence of other binding proteins, such as Gab1 and SOS, to the activated EGF receptor [1].

References

  1. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. Tashiro, K., Tsunematsu, T., Okubo, H., Ohta, T., Sano, E., Yamauchi, E., Taniguchi, H., Konishi, H. J. Biol. Chem. (2009) [Pubmed]
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