The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

EGF  -  epidermal growth factor

Homo sapiens

Synonyms: HOMG4, Pro-epidermal growth factor, URG
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of EGF

  • An antibody to EGFR abolished the tyrosine phosphorylation induced by EGF and transforming growth factor-alpha (TGF-alpha) but only partially blocked that produced by gp30 in SK-BR-3 breast cancer cells [1].
  • In the present study, we have investigated the biochemical mechanism of growth inhibition in A431 human squamous carcinoma cells exposed to exogenous EGF [2].
  • Human EGFR-3 (HER3)/ERBB3 is a recently identified protein related to the EGFR that is widely expressed in breast carcinomas and is a candidate receptor for EGF-like growth factors [3].
  • ITs were expressed from fusion cDNAs combining a single-chain antibody fragment (scFv) directed against the Erb-B2 or epidermal growth factor (EGF) receptors with a truncated Pseudomonas exotoxin A fragment devoid of its cell-binding domain [4].
  • Epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) are potent mitogens that regulate proliferation of prostate cancer cells via autocrine and paracrine loops and promote tumor metastasis [5].
  • Because a high percentage of human carcinomas express EGF-like ligands, our findings suggest a novel mechanism for osteolytic lesions caused by cancer cells metastasizing to bone [6].
  • These results indicate that maintenance of human brain tumor stem cells absolutely requires epidermal growth factor and that tyrosine kinase inhibitors of epidermal growth factor signaling potentially inhibit proliferation and induce apoptosis of these cells [7].
  • Immunofluorescence study confirmed that KB-R7785 inhibited HB-EGF-CTF nuclear translocation under conditions of proHB-EGF shedding induction by 12-O-tetradecanoylphorbol-13-acetate in gastric cancer cells [8].
  • Higher serum EGF levels were found in GERD patients carrying G/G compared with A/A or A/G (P = 0.03, Wilcoxon rank sum test) [9].
  • The results support a model in which AR transcriptional activity increases castration-recurrent prostate cancer cell growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmic shuttling through interactions with the Ku-70/80 regulatory complex [10].
  • Whereas hypoxia enhanced apoptosis and increased phosphorylation of both BADser136 and BADser155, hypoxia diminished phosphorylation of BADser112, and this effect was reversible by EGF [11].

Psychiatry related information on EGF

  • The existence of an autocrine loop for self-stimulation of growth in malignant cells has been proposed for transforming growth factor-alpha (TGF alpha) and its receptor, the epidermal growth factor (EGF) receptor, in a variety of malignant cell types [12].
  • Moreover, the time response of the stimulation of trans-acting factor binding by EGF suggests that the effect is directly due to growth factor and not mediated by changes in growth state [13].
  • Mutations in the EGF repeats of the human Notch 3 receptor lead to the vascular dementia disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) [14].
  • Therefore, to determine whether neonatal EGF treatment would accelerate or inhibit the progression of the PKD in bpk mice, we administered exogenous EGF (1 microgram/g body weight subcutaneously) daily from postnatal days 3-9 (a critical period for tubule maturation) [15].
  • The EGF receptors expressed in the AA hybrids were proven to be of human nature by immunoprecipitation of the receptors cross-linked with [125I]EGF [16].

High impact information on EGF


Chemical compound and disease context of EGF


Biological context of EGF


Anatomical context of EGF

  • Thus, TGF-alpha and EGF are critical regulatory molecules for production of TE cell-derived cytokines within the thymus and may function as key modulators of human T cell development in vivo [33].
  • U73122 did not affect EGF-induced thymidine incorporation in these motility-responsive infectant cell lines [34].
  • EGF redistributes beta2-chimaerin to promote its association with the small GTPase Rac1 at the plasma membrane, as determined by FRET [35].
  • Mature adult parenchymal hepatocytes, typically of restricted capacity to proliferate in culture, can now enter into clonal growth under the influence of hepatocyte growth factor (scatter factor) (HGF/SF), epidermal growth factor (EGF), and transforming growth factor alpha (TGFalpha) in the presence of a new chemically defined medium (HGM) [36].
  • Each oocyte could express over 1 x 10(10) receptors of a single affinity class and these were able to bind and rapidly internalize EGF [37].

Associations of EGF with chemical compounds

  • Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras [38].
  • The rate of oocyte maturation was proportional to hEGF-R occupancy and was significantly faster than progesterone-induced maturation at nanomolar EGF concentrations [37].
  • Both the EGF-induced hyperphosphorylation and the transcriptional activation of the unliganded ER depend on a phosphorylatable serine residue at position 118 [39].
  • Because SH2 domains bind specifically to protein sequences containing phosphotyrosine, we examined their capacity to prevent tyrosine dephosphorylation of the EGF and other receptors with tyrosine kinase activity [40].
  • As a first step towards elucidating the mechanism of 'steroid-independent activation' of the ER by the epidermal growth factor (EGF), we have mapped the ER target domain and determined the signaling pathway [39].
  • Both the beta4 integrin ligand-binding and cytoplasmic domains together with EGF were required for the synergistic activation of a Rac-dependent signaling pathway that was essential for keratinocyte directional migration in response to a galvanotactic stimulus [41].
  • The epidermal growth factor (EGF) receptor directly phosphorylates PIPKIgamma661 at tyrosine 634, and this event is required for EGF-induced migration [42].
  • Before EGF stimulation, integrin alpha2 and EGF receptors were associated based on biochemical and immuno-colocalization approaches [43].
  • These findings are consistent with the hypothesis that cellular adhesion modulates phosphorylation of plasma membrane receptor tyrosine kinases relevant for EGF-induced signal transduction processes [44].
  • Inhibition of PKC activity or selective interference of membrane translocation of PKCepsilon and PKCbetaI by RACK interference peptides attenuated EGF-mediated prevention of acetaldehyde-induced increase in inulin permeability and redistribution of occludin and ZO-1 [45].
  • An understanding of the mechanism that results in aberrant phosphorylation of EGF receptor tyrosine residues and derived signaling cascades is crucial for an understanding of molecular mechanisms in cancer development [46].
  • We also characterized the isolation of captured EGF receptor by mechanical contact of the PDMS surface with a chemically functionalized gold film [47].

Physical interactions of EGF

  • Saturation analysis revealed marked differences between the effects of TPA on EGF binding in ER+ and ER- cell lines [48].
  • According to this model, EGF binding to NDF-occupied heterodimers is partially blocked [49].
  • Both in vitro and in vivo DNA binding assay revealed that the CREB binding activity was low in EGF-starved cells, whereas it was induced within 30 min after EGF treatment of A431 cells [50].
  • This reduced binding is not due to an occupation of the receptors by TGF-alpha since the expression level of this mitogen in different KS cell lines does not correlate with their capacity to bind EGF [51].
  • In contrast, binding of radiolabeled uPA reveals an increased number of uPA-binding sites in EGF-treated cells [52].

Enzymatic interactions of EGF

  • Dok-R has previously been shown to associate with the epidermal growth factor receptor (EGFR) and become tyrosine phosphorylated in response to EGF stimulation [53].
  • In NIH 3T3 cells overexpressing EGFR (NIH-EGFR), eps8 becomes rapidly phosphorylated upon EGF stimulation [54].
  • Although JAK1 is phosphorylated in response to EGF, it is not required for STAT activation or for induction of the c-fos gene [55].
  • The chimeric envelope was expressed and incorporated into viral particles, and the EGF domain could be cleaved from the surface of the viral particles by gelatinase A (MMP-2) [26].
  • In this communication we demonstrate that PLC-II (Mr = 145,000) purified from bovine brain can be phosphorylated in vitro in an EGF-dependent manner by the tyrosine kinase activity of the purified EGF receptor [56].

Co-localisations of EGF


Regulatory relationships of EGF

  • PKCzeta activity is required for EGF-induced extracellular signal-regulated kinase (ERK) activation in both normal human adult epidermal keratinocytes and five of seven SCCHN cell lines [59].
  • We have demonstrated previously that EGF stimulates migration and matrix metalloproteinase (MMP)-9-dependent invasion of ovarian cancer cells [60].
  • Our results provide evidence that IGF-I, KGF, and EGF directly activate the AR in the absence of androgens, which means that the androgen-signaling chain may be activated by growth factors in an androgen-depleted environment [61].
  • Here we show that, in the same cell line, IGFBP-3 potentiates DNA synthesis and cell proliferation stimulated by epidermal growth factor (EGF), a potent activator of Ras [62].
  • However, dominant negative Jaks did not affect EGF-induced Stat phosphorylation [63].
  • EGFR activity was shown to be necessary for EGF-induced localization of Endofin, an FYVE domain-containing protein regulated by phosphoinositol lipid and engaged in endosome-mediated receptor modulation [64].
  • Gene expression and deiodination assays have shown that EGF promptly induces a short-lived Dio2 mRNA and enzymatic activity [65].
  • Accordingly, EGF up-regulated GPR30 protein levels, which accumulated predominantly in the intracellular compartment [66].
  • EGF-like repeats from TSP2 and TSP4 also activated EGFR [67].
  • EGF inhibited the expression of the di/tripeptide transport PEPT2 in a renal kidney cell line, indicating a role in regulation of renal clearance of di/tripeptides [68]

Other interactions of EGF


Analytical, diagnostic and therapeutic context of EGF



  1. Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2. Lupu, R., Colomer, R., Zugmaier, G., Sarup, J., Shepard, M., Slamon, D., Lippman, M.E. Science (1990) [Pubmed]
  2. Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition. Fan, Z., Lu, Y., Wu, X., DeBlasio, A., Koff, A., Mendelsohn, J. J. Cell Biol. (1995) [Pubmed]
  3. Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Ciardiello, F., Kim, N., Saeki, T., Dono, R., Persico, M.G., Plowman, G.D., Garrigues, J., Radke, S., Todaro, G.J., Salomon, D.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Purging of mammary carcinoma cells during ex vivo culture of CD34+ hematopoietic progenitor cells with recombinant immunotoxins. Spyridonidis, A., Schmidt, M., Bernhardt, W., Papadimitriou, A., Azemar, M., Wels, W., Groner, B., Henschler, R. Blood (1998) [Pubmed]
  5. Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. Putz, T., Culig, Z., Eder, I.E., Nessler-Menardi, C., Bartsch, G., Grunicke, H., Uberall, F., Klocker, H. Cancer Res. (1999) [Pubmed]
  6. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. Zhu, J., Jia, X., Xiao, G., Kang, Y., Partridge, N.C., Qin, L. J. Biol. Chem. (2007) [Pubmed]
  7. Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells. Soeda, A., Inagaki, A., Oka, N., Ikegame, Y., Aoki, H., Yoshimura, S., Nakashima, S., Kunisada, T., Iwama, T. J. Biol. Chem. (2008) [Pubmed]
  8. Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: a new molecular target therapy for gastric cancer. Shimura, T., Kataoka, H., Ogasawara, N., Kubota, E., Sasaki, M., Tanida, S., Joh, T. Clin. Cancer Res. (2008) [Pubmed]
  9. A functional epidermal growth factor (EGF) polymorphism, EGF serum levels, and esophageal adenocarcinoma risk and outcome. Lanuti, M., Liu, G., Goodwin, J.M., Zhai, R., Fuchs, B.C., Asomaning, K., Su, L., Nishioka, N.S., Tanabe, K.K., Christiani, D.C. Clin. Cancer Res. (2008) [Pubmed]
  10. Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer. Ponguta, L.A., Gregory, C.W., French, F.S., Wilson, E.M. J. Biol. Chem. (2008) [Pubmed]
  11. Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of BAD Serine 112. Humphrey, R.G., Sonnenberg-Hirche, C., Smith, S.D., Hu, C., Barton, A., Sadovsky, Y., Nelson, D.M. Endocrinology (2008) [Pubmed]
  12. Modulation of EGF receptor expression by differentiating agents in human colon carcinoma cell lines. Murphy, L.D., Valverius, E.M., Tsokos, M., Mickley, L.A., Rosen, N., Bates, S.E. Cancer Commun. (1990) [Pubmed]
  13. Regulation of transforming growth factor alpha expression in a growth factor-independent cell line. Howell, G.M., Humphrey, L.E., Ziober, B.L., Awwad, R., Periyasamy, B., Koterba, A., Li, W., Willson, J.K., Coleman, K., Carboni, J., Lynch, M., Brattain, M.G. Mol. Cell. Biol. (1998) [Pubmed]
  14. A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. Karlström, H., Beatus, P., Dannaeus, K., Chapman, G., Lendahl, U., Lundkvist, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice. Nakanishi, K., Gattone, V.H., Sweeney, W.E., Avner, E.D. Pediatr. Nephrol. (2001) [Pubmed]
  16. Genetic analysis of hyperproduction of epidermal growth factor receptors in human epidermoid carcinoma A431 cells. Shimizu, N., Kondo, I., Gamou, S., Behzadian, M.A., Shimizu, Y. Somat. Cell Mol. Genet. (1984) [Pubmed]
  17. EGF receptor activation: push comes to shove. Hubbard, S.R. Cell (2006) [Pubmed]
  18. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J.H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., Yokoyama, S. Cell (2002) [Pubmed]
  19. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Bulman, M.P., Kusumi, K., Frayling, T.M., McKeown, C., Garrett, C., Lander, E.S., Krumlauf, R., Hattersley, A.T., Ellard, S., Turnpenny, P.D. Nat. Genet. (2000) [Pubmed]
  20. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S.H., Mobley, W.C., Soriano, P., Brodsky, F.M. Cell (1999) [Pubmed]
  21. Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly. Putnam, E.A., Zhang, H., Ramirez, F., Milewicz, D.M. Nat. Genet. (1995) [Pubmed]
  22. Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Migliaccio, A., Di Domenico, M., Castoria, G., Nanayakkara, M., Lombardi, M., de Falco, A., Bilancio, A., Varricchio, L., Ciociola, A., Auricchio, F. Cancer Res. (2005) [Pubmed]
  23. Estrogen negatively regulates epidermal growth factor (EGF)-mediated signal transducer and activator of transcription 5 signaling in human EGF family receptor-overexpressing breast cancer cells. Boerner, J.L., Gibson, M.A., Fox, E.M., Posner, E.D., Parsons, S.J., Silva, C.M., Shupnik, M.A. Mol. Endocrinol. (2005) [Pubmed]
  24. Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. Ye, D., Mendelsohn, J., Fan, Z. Clin. Cancer Res. (1999) [Pubmed]
  25. Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis. Stonecypher, M.S., Chaudhury, A.R., Byer, S.J., Carroll, S.L. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  26. A gene delivery system activatable by disease-associated matrix metalloproteinases. Peng, K.W., Morling, F.J., Cosset, F.L., Murphy, G., Russell, S.J. Hum. Gene Ther. (1997) [Pubmed]
  27. Apoptotic epidermal growth factor (EGF)-conjugated block copolymer micelles as a nanotechnology platform for targeted combination therapy. Lee, H., Hu, M., Reilly, R.M., Allen, C. Mol. Pharm. (2007) [Pubmed]
  28. Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. Meisenhelder, J., Suh, P.G., Rhee, S.G., Hunter, T. Cell (1989) [Pubmed]
  29. Epidermal growth factor receptor distribution in burn wounds. Implications for growth factor-mediated repair. Wenczak, B.A., Lynch, J.B., Nanney, L.B. J. Clin. Invest. (1992) [Pubmed]
  30. FAK integrates growth-factor and integrin signals to promote cell migration. Sieg, D.J., Hauck, C.R., Ilic, D., Klingbeil, C.K., Schaefer, E., Damsky, C.H., Schlaepfer, D.D. Nat. Cell Biol. (2000) [Pubmed]
  31. The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Lee, C.S., Kim, I.S., Park, J.B., Lee, M.N., Lee, H.Y., Suh, P.G., Ryu, S.H. Nat. Cell Biol. (2006) [Pubmed]
  32. Heparin-binding ligands mediate autocrine epidermal growth factor receptor activation In skin organ culture. Stoll, S., Garner, W., Elder, J. J. Clin. Invest. (1997) [Pubmed]
  33. Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level. Le, P.T., Lazorick, S., Whichard, L.P., Haynes, B.F., Singer, K.H. J. Exp. Med. (1991) [Pubmed]
  34. Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. Chen, P., Xie, H., Sekar, M.C., Gupta, K., Wells, A. J. Cell Biol. (1994) [Pubmed]
  35. Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. Wang, H., Yang, C., Leskow, F.C., Sun, J., Canagarajah, B., Hurley, J.H., Kazanietz, M.G. EMBO J. (2006) [Pubmed]
  36. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. Block, G.D., Locker, J., Bowen, W.C., Petersen, B.E., Katyal, S., Strom, S.C., Riley, T., Howard, T.A., Michalopoulos, G.K. J. Cell Biol. (1996) [Pubmed]
  37. Functional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes. Opresko, L.K., Wiley, H.S. J. Cell Biol. (1990) [Pubmed]
  38. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Gale, N.W., Kaplan, S., Lowenstein, E.J., Schlessinger, J., Bar-Sagi, D. Nature (1993) [Pubmed]
  39. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. Bunone, G., Briand, P.A., Miksicek, R.J., Picard, D. EMBO J. (1996) [Pubmed]
  40. SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. Rotin, D., Margolis, B., Mohammadi, M., Daly, R.J., Daum, G., Li, N., Fischer, E.H., Burgess, W.H., Ullrich, A., Schlessinger, J. EMBO J. (1992) [Pubmed]
  41. beta4 integrin and epidermal growth factor coordinately regulate electric field-mediated directional migration via Rac1. Pullar, C.E., Baier, B.S., Kariya, Y., Russell, A.J., Horst, B.A., Marinkovich, M.P., Isseroff, R.R. Mol. Biol. Cell (2006) [Pubmed]
  42. Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration. Sun, Y., Ling, K., Wagoner, M.P., Anderson, R.A. J. Cell Biol. (2007) [Pubmed]
  43. Activated epidermal growth factor receptor induces integrin alpha2 internalization via caveolae/raft-dependent endocytic pathway. Ning, Y., Buranda, T., Hudson, L.G. J. Biol. Chem. (2007) [Pubmed]
  44. Quantitation of multisite EGF receptor phosphorylation using mass spectrometry and a novel normalization approach. Boeri Erba, E., Matthiesen, R., Bunkenborg, J., Schulze, W.X., Di Stefano, P., Cabodi, S., Tarone, G., Defilippi, P., Jensen, O.N. J. Proteome Res. (2007) [Pubmed]
  45. Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers. Suzuki, T., Seth, A., Rao, R. J. Biol. Chem. (2008) [Pubmed]
  46. Quantitative mass spectrometry to investigate epidermal growth factor receptor phosphorylation dynamics. Schuchardt, S., Borlak, J. Mass. Spectrom. Rev (2008) [Pubmed]
  47. Engineering of PDMS surfaces for use in microsystems for capture and isolation of complex and biomedically important proteins: epidermal growth factor receptor as a model system. Lowe, A.M., Ozer, B.H., Wiepz, G.J., Bertics, P.J., Abbott, N.L. Lab. Chip (2008) [Pubmed]
  48. Differential effects of phorbol ester on epidermal growth factor receptors in estrogen receptor-positive and -negative breast cancer cell lines. Koga, M., Musgrove, E.A., Sutherland, R.L. Cancer Res. (1990) [Pubmed]
  49. Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases. Karunagaran, D., Tzahar, E., Liu, N., Wen, D., Yarden, Y. J. Biol. Chem. (1995) [Pubmed]
  50. Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. Wang, J.M., Tseng, J.T., Chang, W.C. Mol. Biol. Cell (2005) [Pubmed]
  51. Low mitogenic response to EGF and TGF-alpha: a characteristic feature of cultured Kaposi's sarcoma derived cells. Werner, S., Viehweger, P., Hofschneider, P.H., Roth, W.K. Oncogene (1991) [Pubmed]
  52. Paracrine stimulation of capillary endothelial cell migration by endometrial tissue involves epidermal growth factor and is mediated via up-regulation of the urokinase plasminogen activator receptor. Sandberg, T., Ehinger, A., Casslén, B. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  53. Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk. Van Slyke, P., Coll, M.L., Master, Z., Kim, H., Filmus, J., Dumont, D.J. Mol. Cell. Biol. (2005) [Pubmed]
  54. Constitutive phosphorylation of eps8 in tumor cell lines: relevance to malignant transformation. Matoskova, B., Wong, W.T., Salcini, A.E., Pelicci, P.G., Di Fiore, P.P. Mol. Cell. Biol. (1995) [Pubmed]
  55. Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Leaman, D.W., Pisharody, S., Flickinger, T.W., Commane, M.A., Schlessinger, J., Kerr, I.M., Levy, D.E., Stark, G.R. Mol. Cell. Biol. (1996) [Pubmed]
  56. Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. Nishibe, S., Wahl, M.I., Rhee, S.G., Carpenter, G. J. Biol. Chem. (1989) [Pubmed]
  57. Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre. Martinu, L., Santiago-Walker, A., Qi, H., Chou, M.M. J. Biol. Chem. (2002) [Pubmed]
  58. Caveolin-1 isoform reorganization studied by image correlation spectroscopy. Nohe, A., Keating, E., Loh, C., Underhill, M.T., Petersen, N.O. Faraday Discuss. (2004) [Pubmed]
  59. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cohen, E.E., Lingen, M.W., Zhu, B., Zhu, H., Straza, M.W., Pierce, C., Martin, L.E., Rosner, M.R. Cancer Res. (2006) [Pubmed]
  60. Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association. Ellerbroek, S.M., Halbleib, J.M., Benavidez, M., Warmka, J.K., Wattenberg, E.V., Stack, M.S., Hudson, L.G. Cancer Res. (2001) [Pubmed]
  61. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Culig, Z., Hobisch, A., Cronauer, M.V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., Klocker, H. Cancer Res. (1994) [Pubmed]
  62. Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. Involvement of p44/42 and p38 mitogen-activated protein kinases. Martin, J.L., Weenink, S.M., Baxter, R.C. J. Biol. Chem. (2003) [Pubmed]
  63. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. Olayioye, M.A., Beuvink, I., Horsch, K., Daly, J.M., Hynes, N.E. J. Biol. Chem. (1999) [Pubmed]
  64. Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells. Chen, Y., Low, T.Y., Choong, L.Y., Ray, R.S., Tan, Y.L., Toy, W., Lin, Q., Ang, B.K., Wong, C.H., Lim, S., Li, B., Hew, C.L., Sze, N.S., Druker, B.J., Lim, Y.P. Proteomics (2007) [Pubmed]
  65. Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells. Canettieri, G., Franchi, A., Guardia, M.D., Morantte, I., Santaguida, M.G., Harney, J.W., Larsen, P.R., Centanni, M. Endocrinology (2008) [Pubmed]
  66. Epidermal growth factor induces G protein-coupled receptor 30 expression in estrogen receptor-negative breast cancer cells. Albanito, L., Sisci, D., Aquila, S., Brunelli, E., Vivacqua, A., Madeo, A., Lappano, R., Pandey, D.P., Picard, D., Mauro, L., Andò, S., Maggiolini, M. Endocrinology (2008) [Pubmed]
  67. Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cgamma and increase epithelial cell migration through indirect epidermal growth factor receptor activation. Liu, A., Garg, P., Yang, S., Gong, P., Pallero, M.A., Annis, D.S., Liu, Y., Passaniti, A., Mann, D., Mosher, D.F., Murphy-Ullrich, J.E., Goldblum, S.E. J. Biol. Chem. (2009) [Pubmed]
  68. Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2. Bravo, S.A., Nielsen, C.U., Amstrup, J., Frokjaer, S., Brodin, B. Am. J. Physiol. Renal. Physiol. (2004) [Pubmed]
  69. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Shuai, K., Ziemiecki, A., Wilks, A.F., Harpur, A.G., Sadowski, H.B., Gilman, M.Z., Darnell, J.E. Nature (1993) [Pubmed]
  70. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Kurten, R.C., Cadena, D.L., Gill, G.N. Science (1996) [Pubmed]
  71. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. Gschwind, A., Hart, S., Fischer, O.M., Ullrich, A. EMBO J. (2003) [Pubmed]
  72. Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor. Swindle, C.S., Tran, K.T., Johnson, T.D., Banerjee, P., Mayes, A.M., Griffith, L., Wells, A. J. Cell Biol. (2001) [Pubmed]
  73. Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Plowman, G.D., Whitney, G.S., Neubauer, M.G., Green, J.M., McDonald, V.L., Todaro, G.J., Shoyab, M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  74. Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Kasper, M., Schnidar, H., Neill, G.W., Hanneder, M., Klingler, S., Blaas, L., Schmid, C., Hauser-Kronberger, C., Regl, G., Philpott, M.P., Aberger, F. Mol. Cell. Biol. (2006) [Pubmed]
  75. Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Graus-Porta, D., Beerli, R.R., Hynes, N.E. Mol. Cell. Biol. (1995) [Pubmed]
WikiGenes - Universities