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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IPPK  -  inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Homo sapiens

Synonyms: C9orf12, FLJ13163, INSP5K2, IP5K, IPK1, ...
 
 
 
 
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High impact information on IPPK

  • Cells that overexpress InsP5 2-kinase have increased levels of InsP6 and are also protected from TNFalpha-induced apoptosis; furthermore, cells that express an RNA interference construct to the 2-kinase are deficient in InsP6 and are sensitized to TNFalpha-induced apoptosis [1].

References

  1. Increased levels of inositol hexakisphosphate (InsP6) protect HEK293 cells from tumor necrosis factor (alpha)- and Fas-induced apoptosis. Verbsky, J., Majerus, P.W. J. Biol. Chem. (2005) [Pubmed]
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