Gene Review:
Ippk
-
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Mus musculus
Synonyms:
1810043M15Rik, Inositol-1,3,4,5,6-pentakisphosphate 2-kinase, Inositol-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase, InsP5 2-kinase, ...
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High impact information on Ippk
- Intense staining was also seen in the yolk sac, suggesting that InsP6 is necessary for yolk sac development or function [1].
- Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression [1].
- Many functions have been suggested for inositol 1,2,3,4,5,6-hexakisphosphate (InsP6), including mRNA export, nonhomologous end-joining, endocytosis, and ion channel regulation [1].
- We previously isolated a cDNA encoding the mammalian inositol 1,3,4,5,6-pentakisphosphate (InsP5) 2-kinase (2-kinase), the enzyme that converts InsP5 to InsP6 [1].
- The abundant metabolite myo-inositol hexakisphosphate (InsP6) can form vesicular deposits with cations, a widespread phenomenon in plants also found in the cestode parasite, Echinococcus granulosus [2].
Biological context of Ippk
- The compound appears to be a subproduct of the intracellular pathways leading to the synthesis and vesicular accumulation of InsP6, rather than arising from extracellular hydrolysis of InsP6 [2].
Associations of Ippk with chemical compounds
- The major inositol phosphate in the deposits, other than InsP6, is myo-inositol (1,2,4,5,6) pentakisphosphate, or its enantiomer, inositol (2,3,4,5,6) pentakisphosphate [2].
References
