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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

RNA Interference

 
 
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Disease relevance of RNA Interference

  • Conversely, knockdown of PRAME expression by RNA interference in RA-resistant human melanoma restores RAR signaling and reinstates sensitivity to the antiproliferative effects of RA in vitro and in vivo [1].
  • Tetanus toxin-mediated inactivation of Gr68a-expressing neurons or transgene-mediated RNA interference of Gr68a RNA leads to a significant reduction in male courtship performance, suggesting that GR68a protein is an essential component of pheromone-driven courtship behavior in Drosophila [2].
  • Knockdown of PARP-1 by RNA interference significantly suppressed both transcriptional activity and proliferation by colorectal cancer cells [3].
  • By retrovirus infection and small interference RNA, we generated SHP overexpressing and SHP-deficient HSC-T6 [4].
  • Functional analysis using RNA interference (RNAi) and combinations of insertion alleles revealed a role for the AML genes in meiosis, with RNAi lines and specific multiple mutant combinations displaying sterility and a range of defects in meiotic chromosome behavior [5].
 

High impact information on RNA Interference

 

Chemical compound and disease context of RNA Interference

 

Biological context of RNA Interference

 

Anatomical context of RNA Interference

 

Associations of RNA Interference with chemical compounds

 

Gene context of RNA Interference

 

Analytical, diagnostic and therapeutic context of RNA Interference

References

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