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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

RNA Interference

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Disease relevance of RNA Interference

  • Conversely, knockdown of PRAME expression by RNA interference in RA-resistant human melanoma restores RAR signaling and reinstates sensitivity to the antiproliferative effects of RA in vitro and in vivo [1].
  • Tetanus toxin-mediated inactivation of Gr68a-expressing neurons or transgene-mediated RNA interference of Gr68a RNA leads to a significant reduction in male courtship performance, suggesting that GR68a protein is an essential component of pheromone-driven courtship behavior in Drosophila [2].
  • Knockdown of PARP-1 by RNA interference significantly suppressed both transcriptional activity and proliferation by colorectal cancer cells [3].
  • By retrovirus infection and small interference RNA, we generated SHP overexpressing and SHP-deficient HSC-T6 [4].
  • Functional analysis using RNA interference (RNAi) and combinations of insertion alleles revealed a role for the AML genes in meiosis, with RNAi lines and specific multiple mutant combinations displaying sterility and a range of defects in meiotic chromosome behavior [5].

High impact information on RNA Interference


Chemical compound and disease context of RNA Interference


Biological context of RNA Interference


Anatomical context of RNA Interference


Associations of RNA Interference with chemical compounds


Gene context of RNA Interference


Analytical, diagnostic and therapeutic context of RNA Interference


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  2. A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship. Bray, S., Amrein, H. Neuron (2003) [Pubmed]
  3. Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex. Idogawa, M., Yamada, T., Honda, K., Sato, S., Imai, K., Hirohashi, S. Gastroenterology (2005) [Pubmed]
  4. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., Morelli, A. Gastroenterology (2004) [Pubmed]
  5. The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Kaur, J., Sebastian, J., Siddiqi, I. Plant Cell (2006) [Pubmed]
  6. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Kissler, S., Stern, P., Takahashi, K., Hunter, K., Peterson, L.B., Wicker, L.S. Nat. Genet. (2006) [Pubmed]
  7. RNAi components are required for nuclear clustering of Polycomb group response elements. Grimaud, C., Bantignies, F., Pal-Bhadra, M., Ghana, P., Bhadra, U., Cavalli, G. Cell (2006) [Pubmed]
  8. Atypical RNA polymerase subunits required for RNA-directed DNA methylation. Kanno, T., Huettel, B., Mette, M.F., Aufsatz, W., Jaligot, E., Daxinger, L., Kreil, D.P., Matzke, M., Matzke, A.J. Nat. Genet. (2005) [Pubmed]
  9. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Rand, T.A., Petersen, S., Du, F., Wang, X. Cell (2005) [Pubmed]
  10. Sex-specific role of Drosophila melanogaster HP1 in regulating chromatin structure and gene transcription. Liu, L.P., Ni, J.Q., Shi, Y.D., Oakeley, E.J., Sun, F.L. Nat. Genet. (2005) [Pubmed]
  11. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Lasorella, A., Iavarone, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  12. TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis. Fukuchi, J., Hiipakka, R.A., Kokontis, J.M., Nishimura, K., Igarashi, K., Liao, S. J. Biol. Chem. (2004) [Pubmed]
  13. Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference. Denkert, C., Fürstenberg, A., Daniel, P.T., Koch, I., Köbel, M., Weichert, W., Siegert, A., Hauptmann, S. Oncogene (2003) [Pubmed]
  14. RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Duxbury, M.S., Ito, H., Benoit, E., Waseem, T., Ashley, S.W., Whang, E.E. Clin. Cancer Res. (2005) [Pubmed]
  15. Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene. Sarot, E., Payen-Groschêne, G., Bucheton, A., Pélisson, A. Genetics (2004) [Pubmed]
  16. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Zhong, Q., Gao, W., Du, F., Wang, X. Cell (2005) [Pubmed]
  17. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Dalmay, T., Hamilton, A., Rudd, S., Angell, S., Baulcombe, D.C. Cell (2000) [Pubmed]
  18. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Noma, K., Sugiyama, T., Cam, H., Verdel, A., Zofall, M., Jia, S., Moazed, D., Grewal, S.I. Nat. Genet. (2004) [Pubmed]
  19. miRNAs on the move: miRNA biogenesis and the RNAi machinery. Murchison, E.P., Hannon, G.J. Curr. Opin. Cell Biol. (2004) [Pubmed]
  20. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Dai, J., Sultan, S., Taylor, S.S., Higgins, J.M. Genes Dev. (2005) [Pubmed]
  21. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Hirota, T., Kunitoku, N., Sasayama, T., Marumoto, T., Zhang, D., Nitta, M., Hatakeyama, K., Saya, H. Cell (2003) [Pubmed]
  22. Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Bhat, M.A., Izaddoost, S., Lu, Y., Cho, K.O., Choi, K.W., Bellen, H.J. Cell (1999) [Pubmed]
  23. The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Teodoro, J.G., Heilman, D.W., Parker, A.E., Green, M.R. Genes Dev. (2004) [Pubmed]
  24. STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Scheeren, F.A., Naspetti, M., Diehl, S., Schotte, R., Nagasawa, M., Wijnands, E., Gimeno, R., Vyth-Dreese, F.A., Blom, B., Spits, H. Nat. Immunol. (2005) [Pubmed]
  25. Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P.J., Adcock, I.M. J. Exp. Med. (2006) [Pubmed]
  26. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Xia, H., Mao, Q., Eliason, S.L., Harper, S.Q., Martins, I.H., Orr, H.T., Paulson, H.L., Yang, L., Kotin, R.M., Davidson, B.L. Nat. Med. (2004) [Pubmed]
  27. Identification of phosphatases for Smad in the BMP/DPP pathway. Chen, H.B., Shen, J., Ip, Y.T., Xu, L. Genes Dev. (2006) [Pubmed]
  28. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Baker-Herman, T.L., Fuller, D.D., Bavis, R.W., Zabka, A.G., Golder, F.J., Doperalski, N.J., Johnson, R.A., Watters, J.J., Mitchell, G.S. Nat. Neurosci. (2004) [Pubmed]
  29. Interactions of GGA3 with the ubiquitin sorting machinery. Puertollano, R., Bonifacino, J.S. Nat. Cell Biol. (2004) [Pubmed]
  30. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Uhlik, M.T., Abell, A.N., Johnson, N.L., Sun, W., Cuevas, B.D., Lobel-Rice, K.E., Horne, E.A., Dell'Acqua, M.L., Johnson, G.L. Nat. Cell Biol. (2003) [Pubmed]
  31. Dicer is essential for mouse development. Bernstein, E., Kim, S.Y., Carmell, M.A., Murchison, E.P., Alcorn, H., Li, M.Z., Mills, A.A., Elledge, S.J., Anderson, K.V., Hannon, G.J. Nat. Genet. (2003) [Pubmed]
  32. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Tabara, H., Sarkissian, M., Kelly, W.G., Fleenor, J., Grishok, A., Timmons, L., Fire, A., Mello, C.C. Cell (1999) [Pubmed]
  33. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Mourrain, P., Béclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Jouette, D., Lacombe, A.M., Nikic, S., Picault, N., Rémoué, K., Sanial, M., Vo, T.A., Vaucheret, H. Cell (2000) [Pubmed]
  34. The role of presenilin cofactors in the gamma-secretase complex. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., Iwatsubo, T. Nature (2003) [Pubmed]
  35. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Okamura, K., Ishizuka, A., Siomi, H., Siomi, M.C. Genes Dev. (2004) [Pubmed]
  36. hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. Sánchez-Velar, N., Udofia, E.B., Yu, Z., Zapp, M.L. Genes Dev. (2004) [Pubmed]
  37. Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres. Maiato, H., Khodjakov, A., Rieder, C.L. Nat. Cell Biol. (2005) [Pubmed]
  38. The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis. Cuff, M., Dyer, J., Jones, M., Shirazi-Beechey, S. Gastroenterology (2005) [Pubmed]
  39. The Rho-associated protein kinase p160ROCK is required for centrosome positioning. Chevrier, V., Piel, M., Collomb, N., Saoudi, Y., Frank, R., Paintrand, M., Narumiya, S., Bornens, M., Job, D. J. Cell Biol. (2002) [Pubmed]
  40. Iron-sulfur protein maturation in human cells: evidence for a function of frataxin. Stehling, O., Elsässer, H.P., Brückel, B., Mühlenhoff, U., Lill, R. Hum. Mol. Genet. (2004) [Pubmed]
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