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Gene Review

Nacc1  -  nucleus accumbens associated 1, BEN and...

Mus musculus

Synonyms: 2010001H03Rik, 4930511N13Rik, BTB/POZ domain-containing protein 14B, Btbd14b, NAC-1, ...
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Disease relevance of Btbd14b

  • In addition, a functional AP1 binding site has been identified in an intron 1 enhancer of the Nac1 gene that plays an essential role in the activation of the gene in differentiation of neuroblastoma cells [1].

High impact information on Btbd14b

  • The mouse Nac1 gene consist of six exons, with exon 2 containing an alternative splice donor, providing a molecular explanation of the splice variants observed in mouse and rat [1].
  • The mouse Nac1 gene was localized to chromosome 8, suggesting a highly plausible candidate gene to explain differences in cocaine-induced behaviors between C57BL6/J and DBA/2J mice that had previously been mapped to the area [1].


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