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Gene Review

Sdhd  -  succinate dehydrogenase complex, subunit D...

Mus musculus

Synonyms: 3110001M13Rik, AVLL5809, C78570, CII-4, CybS, ...
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Disease relevance of Sdhd


Anatomical context of Sdhd

  • Heterozygous Sdhd(+/-) mice show a general, non-compensated, deficiency of complex II activity, and abnormal enhancement of resting carotid body secretion rate due to decrease of K+ conductance and persistent Ca2+ influx into glomus cells [1].


  1. Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells. López-Barneo, J., Ortega-Sáenz, P., Piruat, J.I., García-Fernández, M. Novartis Found. Symp. (2006) [Pubmed]
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