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Gene Review

Snx2  -  sorting nexin 2

Mus musculus

Synonyms: 0610030A03Rik, Sorting nexin-2
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High impact information on Snx2

  • We have previously shown that the putative mammalian retromer components sorting nexins 1 and 2 (Snx1 and Snx2) result in embryonic lethality when simultaneously targeted for deletion in mice, whereas others have shown that Hbeta58 (also known as mVps26), another retromer component, results in similar lethality when targeted for deletion [1].

Other interactions of Snx2

  • Furthermore, the viability of Snx1(-/-) and Snx2(-/-) mice demonstrates that it is not necessary for SNX1 and SNX2 to act together [2].


  1. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Griffin, C.T., Trejo, J., Magnuson, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Schwarz, D.G., Griffin, C.T., Schneider, E.A., Yee, D., Magnuson, T. Mol. Biol. Cell (2002) [Pubmed]
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