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Gene Review

SNX2  -  sorting nexin 2

Homo sapiens

Synonyms: Sorting nexin-2, TRG-9, TRG9, Transformation-related gene 9 protein
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High impact information on SNX2

  • We screened a human kidney library and identified a sorting nexin, SNX2, as a protein interaction partner of FBP17 [1].
  • The association of Vps26-Vps29-Vps35 with endosomes requires the presence of either SNX1 or SNX2, whereas SNX1/2 can be recruited to endosomes independently of Vps26-Vps29-Vps35 [2].
  • Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors [2].
  • We also found that the presence of either SNX1 or SNX2 is essential for the retrieval of the cation-independent mannose 6-phosphate receptor to the TGN [2].
  • We have obtained full-length cDNAs and deduced the amino acid sequences of three novel homologous proteins, which were denoted human sorting nexins (SNX2, SNX3, and SNX4) [3].

Biological context of SNX2


Anatomical context of SNX2


Associations of SNX2 with chemical compounds


Regulatory relationships of SNX2

  • Mutant SNX2 markedly inhibited agonist-induced EGFR degradation, whereas internalization remained intact [4].

Other interactions of SNX2

  • To assess SNX2 function, we examined the effect of a PX domain-mutated SNX2 that is defective in vesicle localization on EGFR trafficking [4].


  1. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Fuchs, U., Rehkamp, G., Haas, O.A., Slany, R., Kōnig, M., Bojesen, S., Bohle, R.M., Damm-Welk, C., Ludwig, W.D., Harbott, J., Borkhardt, A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. Rojas, R., Kametaka, S., Haft, C.R., Bonifacino, J.S. Mol. Cell. Biol. (2007) [Pubmed]
  3. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Haft, C.R., de la Luz Sierra, M., Barr, V.A., Haft, D.H., Taylor, S.I. Mol. Cell. Biol. (1998) [Pubmed]
  4. A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. Gullapalli, A., Garrett, T.A., Paing, M.M., Griffin, C.T., Yang, Y., Trejo, J. Mol. Biol. Cell (2004) [Pubmed]
  5. A large family of endosome-localized proteins related to sorting nexin 1. Teasdale, R.D., Loci, D., Houghton, F., Karlsson, L., Gleeson, P.A. Biochem. J. (2001) [Pubmed]
  6. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. Carlton, J.G., Bujny, M.V., Peter, B.J., Oorschot, V.M., Rutherford, A., Arkell, R.S., Klumperman, J., McMahon, H.T., Cullen, P.J. J. Cell. Sci. (2005) [Pubmed]
  7. Abstrakt interacts with and regulates the expression of sorting nexin-2. Abdul-Ghani, M., Hartman, K.L., Ngsee, J.K. J. Cell. Physiol. (2005) [Pubmed]
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