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Gene Review

Snx1  -  sorting nexin 1

Mus musculus

Synonyms: Sorting nexin-1
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High impact information on Snx1

  • We have previously shown that the putative mammalian retromer components sorting nexins 1 and 2 (Snx1 and Snx2) result in embryonic lethality when simultaneously targeted for deletion in mice, whereas others have shown that Hbeta58 (also known as mVps26), another retromer component, results in similar lethality when targeted for deletion [1].
  • However, tetraploid aggregation experiments suggest that yolk sac defects cannot fully account for Snx1(-/-); Snx2(-/-) embryonic lethality [2].
  • The second clone, YR-14, represents a sorting nexin (SNX14) gene whose expression in vivo coincides with that of LIM-homeodomain Islet-1 in several tissues [3].
  • Association of mouse sorting nexin 1 with early endosomes [4].
  • Sorting nexin 1 (SNX1) is a protein that binds to the cytoplasmic domain of plasma membrane receptors [4].

Biological context of Snx1


Other interactions of Snx1

  • Furthermore, the viability of Snx1(-/-) and Snx2(-/-) mice demonstrates that it is not necessary for SNX1 and SNX2 to act together [2].


  1. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Griffin, C.T., Trejo, J., Magnuson, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Schwarz, D.G., Griffin, C.T., Schneider, E.A., Yee, D., Magnuson, T. Mol. Biol. Cell (2002) [Pubmed]
  3. Sorting nexin-14, a gene expressed in motoneurons trapped by an in vitro preselection method. Carroll, P., Renoncourt, Y., Gayet, O., De Bovis, B., Alonso, S. Dev. Dyn. (2001) [Pubmed]
  4. Association of mouse sorting nexin 1 with early endosomes. Nakamura, N., Sun-Wada, G.H., Yamamoto, A., Wada, Y., Futai, M. J. Biochem. (2001) [Pubmed]
  5. Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90. Yang, W., Jansen, J.M., Lin, Q., Canova, S., Cerione, R.A., Childress, C. Biochem. J. (2004) [Pubmed]
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