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Gene Review

Tceb1  -  transcription elongation factor B (SIII),...

Mus musculus

Synonyms: 2610043E24Rik, 2610301I15Rik, AA407206, AI987979, AW049146, ...
 
 
 
 
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High impact information on Tceb1

  • Amino-acid sequence analysis identified a BC-box element in TMF/ARA160 that mediated the binding of this protein to elongin C. Ectopic expression of TMF/ARA160 in serum-starved C2C12 cells drove the ubiquitination and proteasomal degradation of Stat3, an effect that was not caused by TMF/ARA160 devoid of the BC-box motif [1].

References

  1. TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. Perry, E., Tsruya, R., Levitsky, P., Pomp, O., Taller, M., Weisberg, S., Parris, W., Kulkarni, S., Malovani, H., Pawson, T., Shpungin, S., Nir, U. Oncogene (2004) [Pubmed]
 
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