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Gene Review

TCEB1  -  transcription elongation factor B (SIII),...

Homo sapiens

Synonyms: EloC, Elongin 15 kDa subunit, Elongin-C, RNA polymerase II transcription factor SIII subunit C, SIII, ...
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Disease relevance of TCEB1


High impact information on TCEB1

  • Whereas Elongin C assembles with Elongin A to form an AC complex with increased specific activity, Elongin B, a member of the ubiquitin-homology gene family, appears to serve a chaperone-like function, facilitating assembly and enhancing stability of the Elongin (SIII) complex [4].
  • Vif binding to EloC is negatively regulated by serine phosphorylation in the BC-box motif of the SOCS-box [5].
  • RACK1 binds to Elongin-C and promotes ubiquitination of HIF-1alpha [6].
  • Elongin-C-binding sites in RACK1 and VHL show significant sequence similarity [6].
  • These mutations preferentially involve residues that directly bind to elongin C and/or alter the conformation of pVHL such that binding to elongin C is at least partially diminished [7].

Physical interactions of TCEB1

  • In this report, we identify Elongin C mutants that fall into multiple functional classes based on their abilities to bind Elongin B and to bind and activate Elongin A under our assay conditions [8].

Other interactions of TCEB1


Analytical, diagnostic and therapeutic context of TCEB1

  • These occur in the pVHL regions that bind hypoxia-inducible factor alpha (HIF-alpha ) or Elongin C. Microarray analysis showed that the clones bearing a mutation in the elongin-binding region (mutant 167) were unique, as many more genes were suppressed than up-regulated [13].


  1. Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function. Kobayashi, M., Takaori-Kondo, A., Miyauchi, Y., Iwai, K., Uchiyama, T. J. Biol. Chem. (2005) [Pubmed]
  2. Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2. Groulx, I., Bonicalzi, M.E., Lee, S. J. Biol. Chem. (2000) [Pubmed]
  3. Amplification and overexpression of Elongin C gene discovered in prostate cancer by cDNA microarrays. Porkka, K., Saramäki, O., Tanner, M., Visakorpi, T. Lab. Invest. (2002) [Pubmed]
  4. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Aso, T., Lane, W.S., Conaway, J.W., Conaway, R.C. Science (1995) [Pubmed]
  5. Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. Mehle, A., Goncalves, J., Santa-Marta, M., McPike, M., Gabuzda, D. Genes Dev. (2004) [Pubmed]
  6. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Liu, Y.V., Baek, J.H., Zhang, H., Diez, R., Cole, R.N., Semenza, G.L. Mol. Cell (2007) [Pubmed]
  7. Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein. Ohh, M., Takagi, Y., Aso, T., Stebbins, C.E., Pavletich, N.P., Zbar, B., Conaway, R.C., Conaway, J.W., Kaelin, W.G. J. Clin. Invest. (1999) [Pubmed]
  8. Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A. Takagi, Y., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (1996) [Pubmed]
  9. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein. Takagi, Y., Pause, A., Conaway, R.C., Conaway, J.W. J. Biol. Chem. (1997) [Pubmed]
  10. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Clifford, S.C., Astuti, D., Hooper, L., Maxwell, P.H., Ratcliffe, P.J., Maher, E.R. Oncogene (2001) [Pubmed]
  11. Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. Tsuchiya, H., Iseda, T., Hino, O. Cancer Res. (1996) [Pubmed]
  12. A zinc-binding region in Vif binds Cul5 and determines cullin selection. Mehle, A., Thomas, E.R., Rajendran, K.S., Gabuzda, D. J. Biol. Chem. (2006) [Pubmed]
  13. Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones. Tsuchiya, M.I., Okuda, H., Takaki, Y., Baba, M., Hirai, S., Ohno, S., Shuin, T. Oncol. Rep. (2005) [Pubmed]
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