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Gene Review

MED22  -  mediator complex subunit 22

Homo sapiens

Synonyms: MED24, Med24, Mediator complex subunit 22, Mediator of RNA polymerase II transcription subunit 22, SURF5, ...
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Disease relevance of SURF5

  • Clinical scores of erythema and determination of the MED 24 h after irradiation did not show statistically significant changes between the exposed areas before and after bexarotene treatment or between the two doses tested [1].
  • CONCLUSION: Individuals who surf 5 years or less are unlikely to develop exostoses unless they are surfing greater than 50 sessions per year [2].


  1. Effects of oral bexarotene (targretin) on the minimal erythema dose for broadspectrum UVB light. Smit, J.V., De Jong, E.M., Van De Kerkhof, P.C. Skin Pharmacol. Appl. Skin Physiol. (2003) [Pubmed]
  2. Exostoses of the external auditory canal in Oregon surfers. Deleyiannis, F.W., Cockcroft, B.D., Pinczower, E.F. American journal of otolaryngology. (1996) [Pubmed]
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