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MeSH Review


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Disease relevance of Erythema


Psychiatry related information on Erythema


High impact information on Erythema

  • RESULTS: Erythema migrans developed at the site of the tick bite in a significantly smaller proportion of the subjects in the doxycycline group than of those in the placebo group (1 of 235 subjects [0.4 percent] vs. 8 of 247 subjects [3.2 percent], P<0.04) [7].
  • We hypothesized that the rare persons with the p phenotype, whose erythrocytes do not have this receptor, would be naturally resistant to B19 infection, which causes erythema infectiosum [8].
  • After eight weeks, the eight recipients of cyclosporine had marked improvement in erythema (P = 0.003), erosion (P = 0.02), reticulation (presence of white lacelike lesions; P = 0.007), and pain (P = 0.002), whereas the eight recipients of vehicle had no change or minimal improvement [9].
  • As compared with nonresponders, penicillin-responsive patients in both studies were more likely to have previously received antibiotics for erythema chronicum migrans (P less than 0.02) and less likely to have been given intraarticular corticosteroids during or at the conclusion of parenteral therapy (P less than 0.1) [10].
  • Faster healing and pain resolution occurred both among patients who first applied penciclovir cream in the prodrome and erythema stages and among those who started treatment in the papule and vesicle lesion stages [11].

Chemical compound and disease context of Erythema


Biological context of Erythema


Anatomical context of Erythema


Gene context of Erythema

  • Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme [25].
  • The small increase in interleukin-10 implies that 3 minimal erythema doses of solar-simulated radiation is the threshold dose for its induction and local, rather than systemic, functions for interleukin-10 in immunosuppression and regulation of other cytokines [26].
  • The results consistently indicated the presence of inflammatory quantities of IL-1 alpha-like material, which induced persistent erythema lasting at least 24 h, associated in 4-h biopsies with mixed dermal leukocyte infiltrates containing increased numbers of neutrophils, monocytes, and T helper cells [27].
  • Western analysis revealed that levels of the full-length, 85 kDa proenzyme form of MMP-8 increased significantly within 8 h post ultraviolet irradiation (2 minimal erythema doses) [28].
  • Immunohistochemical studies on two minimal erythema doses (2MED)-exposed and 2MED-unexposed skin from healthy volunteers revealed that CXCR-2 staining occurred over the whole layer of the epidermis but at 24 h after 2MED irradiation, the positive staining of CXCR-2 was decreased [29].

Analytical, diagnostic and therapeutic context of Erythema


  1. Ceftriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. Dattwyler, R.J., Luft, B.J., Kunkel, M.J., Finkel, M.F., Wormser, G.P., Rush, T.J., Grunwaldt, E., Agger, W.A., Franklin, M., Oswald, D., Cockey, L., Maladorno, D. N. Engl. J. Med. (1997) [Pubmed]
  2. Bacterial endotoxin (lipopolysaccharide) as a cause of erythema multiforme. Shelley, W.B. JAMA (1980) [Pubmed]
  3. Acarbose-induced generalised erythema multiforme. Kono, T., Hayami, M., Kobayashi, H., Ishii, M., Taniguchi, S. Lancet (1999) [Pubmed]
  4. A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation. Olver, I.N., Aisner, J., Hament, A., Buchanan, L., Bishop, J.F., Kaplan, R.S. J. Clin. Oncol. (1988) [Pubmed]
  5. Relation between HLA-B27 and clinical features in patients with yersinia arthritis. Laitinen, O., Leirisalo, M., Skylv, G. Arthritis Rheum. (1977) [Pubmed]
  6. Isoenzymes of aldehyde dehydrogenase in human lymphocytes. Dyck, L.E. Alcohol. Clin. Exp. Res. (1990) [Pubmed]
  7. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. Nadelman, R.B., Nowakowski, J., Fish, D., Falco, R.C., Freeman, K., McKenna, D., Welch, P., Marcus, R., Agüero-Rosenfeld, M.E., Dennis, D.T., Wormser, G.P. N. Engl. J. Med. (2001) [Pubmed]
  8. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). Brown, K.E., Hibbs, J.R., Gallinella, G., Anderson, S.M., Lehman, E.D., McCarthy, P., Young, N.S. N. Engl. J. Med. (1994) [Pubmed]
  9. Effect of topical cyclosporine rinse on oral lichen planus. A double-blind analysis. Eisen, D., Ellis, C.N., Duell, E.A., Griffiths, C.E., Voorhees, J.J. N. Engl. J. Med. (1990) [Pubmed]
  10. Successful parenteral penicillin therapy of established Lyme arthritis. Steere, A.C., Green, J., Schoen, R.T., Taylor, E., Hutchinson, G.J., Rahn, D.W., Malawista, S.E. N. Engl. J. Med. (1985) [Pubmed]
  11. Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group. Spruance, S.L., Rea, T.L., Thoming, C., Tucker, R., Saltzman, R., Boon, R. JAMA (1997) [Pubmed]
  12. Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset. Haslett, P.A., Corral, L.G., Albert, M., Kaplan, G. J. Exp. Med. (1998) [Pubmed]
  13. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. A mechanism for irradiation erythema. Pentland, A.P., Mahoney, M., Jacobs, S.C., Holtzman, M.J. J. Clin. Invest. (1990) [Pubmed]
  14. Acyclovir therapy for acute herpes zoster. Bean, B., Braun, C., Balfour, H.H. Lancet (1982) [Pubmed]
  15. Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Kragballe, K., Gjertsen, B.T., De Hoop, D., Karlsmark, T., van de Kerkhof, P.C., Larkö, O., Nieboer, C., Roed-Petersen, J., Strand, A., Tikjøb, G. Lancet (1991) [Pubmed]
  16. The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). Reshef, A., Kagey-Sobotka, A., Adkinson, N.F., Lichtenstein, L.M., Norman, P.S. J. Allergy Clin. Immunol. (1989) [Pubmed]
  17. Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study. Lin, R.Y., Schwartz, L.B., Curry, A., Pesola, G.R., Knight, R.J., Lee, H.S., Bakalchuk, L., Tenenbaum, C., Westfal, R.E. J. Allergy Clin. Immunol. (2000) [Pubmed]
  18. Effects of oral vitamin E and beta-carotene supplementation on ultraviolet radiation-induced oxidative stress in human skin. McArdle, F., Rhodes, L.E., Parslew, R.A., Close, G.L., Jack, C.I., Friedmann, P.S., Jackson, M.J. Am. J. Clin. Nutr. (2004) [Pubmed]
  19. Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity. Kerb, R., Brockmöller, J., Reum, T., Roots, I. J. Invest. Dermatol. (1997) [Pubmed]
  20. COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Buckman, S.Y., Gresham, A., Hale, P., Hruza, G., Anast, J., Masferrer, J., Pentland, A.P. Carcinogenesis (1998) [Pubmed]
  21. Comparison of effects of topical levocabastine and nedocromil sodium on the early response in a conjunctival provocation test with allergen. Hammann, C., Kämmerer, R., Gerber, M., Spertini, F. J. Allergy Clin. Immunol. (1996) [Pubmed]
  22. Herpes simplex virus associated erythema multiforme (HAEM) is mechanistically distinct from drug-induced erythema multiforme: interferon-gamma is expressed in HAEM lesions and tumor necrosis factor-alpha in drug-induced erythema multiforme lesions. Kokuba, H., Aurelian, L., Burnett, J. J. Invest. Dermatol. (1999) [Pubmed]
  23. Multiple topical applications of arachidonic acid to mouse ears induce inflammatory and proliferative changes. Doherty, N.S., Beaver, T.H., Rheins, L.A., Nordlund, J.J. J. Invest. Dermatol. (1988) [Pubmed]
  24. Surfactants cause in vitro chemotaxis and chemokinesis of human neutrophils. Frosch, P.J., Czarnetzki, B.M. J. Invest. Dermatol. (1987) [Pubmed]
  25. Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. Brown, L.F., Harrist, T.J., Yeo, K.T., Ståhle-Bäckdahl, M., Jackman, R.W., Berse, B., Tognazzi, K., Dvorak, H.F., Detmar, M. J. Invest. Dermatol. (1995) [Pubmed]
  26. Suppressed alloantigen presentation, increased TNF-alpha, IL-1, IL-1Ra, IL-10, and modulation of TNF-R in UV-irradiated human skin. Barr, R.M., Walker, S.L., Tsang, W., Harrison, G.I., Ettehadi, P., Greaves, M.W., Young, A.R. J. Invest. Dermatol. (1999) [Pubmed]
  27. Potent inflammatory properties in human skin of interleukin-1 alpha-like material isolated from normal skin. Camp, R., Fincham, N., Ross, J., Bird, C., Gearing, A. J. Invest. Dermatol. (1990) [Pubmed]
  28. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo. Fisher, G.J., Choi, H.C., Bata-Csorgo, Z., Shao, Y., Datta, S., Wang, Z.Q., Kang, S., Voorhees, J.J. J. Invest. Dermatol. (2001) [Pubmed]
  29. Downregulation of CXCR-2 but not CXCR-1 expression by human keratinocytes by UVB. Kondo, S., Yoneta, A., Yazawa, H., Kamada, A., Jimbow, K. J. Cell. Physiol. (2000) [Pubmed]
  30. Occupational risk of human parvovirus B19 infection for school and day-care personnel during an outbreak of erythema infectiosum. Gillespie, S.M., Cartter, M.L., Asch, S., Rokos, J.B., Gary, G.W., Tsou, C.J., Hall, D.B., Anderson, L.J., Hurwitz, E.S. JAMA (1990) [Pubmed]
  31. The association of allergen skin test reactivity and respiratory disease among whites in the US population. Data from the Second National Health and Nutrition Examination Survey, 1976 to 1980. Gergen, P.J., Turkeltaub, P.C. Arch. Intern. Med. (1991) [Pubmed]
  32. Topical benzoic acid induces the increased biosynthesis of prostaglandin D2 in human skin in vivo. Downard, C.D., Roberts, L.J., Morrow, J.D. Clin. Pharmacol. Ther. (1995) [Pubmed]
  33. HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity. Fuchs, J., Weber, S., Podda, M., Groth, N., Herrling, T., Packer, L., Kaufmann, R. Free Radic. Biol. Med. (2003) [Pubmed]
  34. Fatal anaphylactoid response to protamine after percutaneous transluminal coronary angioplasty. Neidhart, P.P., Meier, B., Polla, B.S., Schifferli, J.A., Morel, D.R. Eur. Heart J. (1992) [Pubmed]
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