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Gene Review

Ddah1  -  dimethylarginine dimethylaminohydrolase 1

Mus musculus

Synonyms: 2410006N07Rik, 2510015N06Rik, AI987801, AW050362, DDAH-1, ...
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Disease relevance of Ddah1

  • Overexpression of DDAH results in increased neovascularization of C6 gliomas in vivo [1].
  • In normal mice, hindlimb ischemia increased tissue ADMA twofold, and reduced DDAH and NOS expression [2].

High impact information on Ddah1

  • The lack of significant difference in hypercapnic/hyperoxic response between the C6 and D27 tumors and the similar vessel caliber are also consistent with a role for DDAH in the initial stages of vasculogenesis [1].
  • In DDAH transgenic mice, the elevation of ADMA and decrement in NOS activity was blunted during hindlimb ischemia [2].

Chemical compound and disease context of Ddah1


  1. Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging. Kostourou, V., Robinson, S.P., Whitley, G.S., Griffiths, J.R. Cancer Res. (2003) [Pubmed]
  2. ADMA regulates angiogenesis: genetic and metabolic evidence. Achan, V., Ho, H.K., Heeschen, C., Stuehlinger, M., Jang, J.J., Kimoto, M., Vallance, P., Cooke, J.P. Vascular medicine (London, England) (2005) [Pubmed]
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