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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TRGC2  -  T cell receptor gamma constant 2

Homo sapiens

Synonyms: T-cell receptor gamma chain C region PT-gamma-1/2, T-cell receptor gamma-2 chain C region, TCRGC2, TRGC2(2X), TRGC2(3X)
 
 
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High impact information on TRGC2

  • We have identified such negative cis-acting sequences in the 3' non-coding region of the human TcR gamma (TRG) locus, upstream of an enhancer located at 6.5 kb of the TcR C gamma 2 gene (TRGC2) [1].
  • The allelic polymorphisms at exon 3 and exon 2 of the T cell receptor (TCR) C gamma 2 (TRGC2) gene, generating 18-kb and 5.4-kb HindIII fragments, respectively, were found to be more frequent in multibacillary leprosy patients than in the controls (P < 0.005 and P < 0.001, respectively) when screened with the IDP2.11 probe [2].
  • The constant gamma 1 gene, TRGC1, consists of three exons, whereas the TRGC2 gene contains four or five exons due to the duplication or triplication of exon 2 and spans 9.5 kb or 12 kb, respectively [3].
  • We show also that the cDNA of the HPB-MLT cell line results from the transcription of an allelic TRGC2 gene with duplicated exon 2 [3].

References

  1. gamma delta lineage-specific transcription of human T cell receptor gamma genes by a combination of a non-lineage-specific enhancer and silencers. Lefranc, M.P., Alexandre, D. Eur. J. Immunol. (1995) [Pubmed]
  2. Genetic variations at the T cell receptor gamma locus in circulating peripheral blood mononuclear cells of clinically categorised leprosy patients. Sachdeva, G., Kaur, G., Bhutani, L.K., Bamezai, R. Hum. Genet. (1997) [Pubmed]
  3. Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and black African populations. Buresi, C., Ghanem, N., Huck, S., Lefranc, G., Lefranc, M.P. Immunogenetics (1989) [Pubmed]
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