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Gene Review:

Mmrn1 - multimerin 1

Mus musculus

Synonyms: 4921530G03Rik, Emilin4, Mmrn, Multimerin-1

Gajović, S. et al., Braghetta, P. et al., Specht, C.G. et al.

Gajović, Mitrecić, Augustincić, Iaconcig, Muro,

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High impact information on Mmrn1

Detailed mapping and sequencing of the breakpoint revealed the absence of 365 kb, encompassing the Mmrn1 gene in addition to Snca [1].
Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family [2].
The fact that Add2 knockout was compared with the C57BL/6JOlaHsd mouse strain, which is actually a double knockout of Snca and Mmrn1 emphasizes a need for information provided by commercial suppliers and of exact denominations of substrains used in research [3].

Biological context of Mmrn1

Despite the lack of alpha-synuclein and multimerin-1 C57BL/6JOlaHsd animals do not display obvious phenotypes [1].

Analytical, diagnostic and therapeutic context of Mmrn1

In situ hybridization has revealed that the EMILIN/Multimerin genes are particularly expressed in the cardio-vascular system and in mesenchymal cells [2].

References

Deletion of multimerin-1 in alpha-synuclein-deficient mice. Specht, C.G., Schoepfer, R. Genomics (2004) [Pubmed]
Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family. Braghetta, P., Ferrari, A., De Gemmis, P., Zanetti, M., Volpin, D., Bonaldo, P., Bressan, G.M. Matrix Biol. (2004) [Pubmed]
Unexpected Rescue of Alpha-synuclein and Multimerin1 Deletion in C57BL/6JOlaHsd Mice by Beta-adducin Knockout. Gajović, S., Mitrecić, D., Augustincić, L., Iaconcig, A., Muro, A.F. Transgenic Res. (2006) [Pubmed]

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