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Gene Review

Snca  -  synuclein, alpha

Mus musculus

Synonyms: Alpha-synuclein, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Syn, ...
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Disease relevance of Snca


Psychiatry related information on Snca


High impact information on Snca


Chemical compound and disease context of Snca


Biological context of Snca


Anatomical context of Snca


Associations of Snca with chemical compounds


Physical interactions of Snca


Co-localisations of Snca


Regulatory relationships of Snca


Other interactions of Snca


Analytical, diagnostic and therapeutic context of Snca


  1. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. Kahle, P.J., Neumann, M., Ozmen, L., Muller, V., Jacobsen, H., Schindzielorz, A., Okochi, M., Leimer, U., van Der Putten, H., Probst, A., Kremmer, E., Kretzschmar, H.A., Haass, C. J. Neurosci. (2000) [Pubmed]
  2. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Kahle, P.J., Neumann, M., Ozmen, L., Müller, V., Odoy, S., Okamoto, N., Jacobsen, H., Iwatsubo, T., Trojanowski, J.Q., Takahashi, H., Wakabayashi, K., Bogdanovic, N., Riederer, P., Kretzschmar, H.A., Haass, C. Am. J. Pathol. (2001) [Pubmed]
  3. Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. Peng, X., Peng, X.M., Tehranian, R., Dietrich, P., Stefanis, L., Perez, R.G. J. Cell. Sci. (2005) [Pubmed]
  4. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. Robertson, D.C., Schmidt, O., Ninkina, N., Jones, P.A., Sharkey, J., Buchman, V.L. J. Neurochem. (2004) [Pubmed]
  5. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Yazawa, I., Giasson, B.I., Sasaki, R., Zhang, B., Joyce, S., Uryu, K., Trojanowski, J.Q., Lee, V.M. Neuron (2005) [Pubmed]
  6. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Gallardo, G., Schlüter, O.M., Südhof, T.C. Nat. Neurosci. (2008) [Pubmed]
  7. Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development. Hsu, L.J., Mallory, M., Xia, Y., Veinbergs, I., Hashimoto, M., Yoshimoto, M., Thal, L.J., Saitoh, T., Masliah, E. J. Neurochem. (1998) [Pubmed]
  8. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Fornai, F., Schlüter, O.M., Lenzi, P., Gesi, M., Ruffoli, R., Ferrucci, M., Lazzeri, G., Busceti, C.L., Pontarelli, F., Battaglia, G., Pellegrini, A., Nicoletti, F., Ruggieri, S., Paparelli, A., Südhof, T.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Brain reward in the absence of alpha-synuclein. Oksman, M., Tanila, H., Yavich, L. Neuroreport (2006) [Pubmed]
  10. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., Mucke, L. Science (2000) [Pubmed]
  11. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Giasson, B.I., Duda, J.E., Quinn, S.M., Zhang, B., Trojanowski, J.Q., Lee, V.M. Neuron (2002) [Pubmed]
  12. Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Schlüter, O.M., Fornai, F., Alessandrí, M.G., Takamori, S., Geppert, M., Jahn, R., Südhof, T.C. Neuroscience (2003) [Pubmed]
  13. Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. Martín, E.D., González-García, C., Milán, M., Fariñas, I., Ceña, V. Eur. J. Neurosci. (2004) [Pubmed]
  14. Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Klein, R.L., Dayton, R.D., Henderson, K.M., Petrucelli, L. Neurosci. Lett. (2006) [Pubmed]
  15. Quinacrine acts as an antioxidant and reduces the toxicity of the prion peptide PrP106-126. Turnbull, S., Tabner, B.J., Brown, D.R., Allsop, D. Neuroreport (2003) [Pubmed]
  16. Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. Drolet, R.E., Behrouz, B., Lookingland, K.J., Goudreau, J.L. Neurotoxicology (2004) [Pubmed]
  17. Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Ellis, C.E., Murphy, E.J., Mitchell, D.C., Golovko, M.Y., Scaglia, F., Barceló-Coblijn, G.C., Nussbaum, R.L. Mol. Cell. Biol. (2005) [Pubmed]
  18. Deletion of multimerin-1 in alpha-synuclein-deficient mice. Specht, C.G., Schoepfer, R. Genomics (2004) [Pubmed]
  19. alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons. Rideout, H.J., Dietrich, P., Wang, Q., Dauer, W.T., Stefanis, L. J. Biol. Chem. (2004) [Pubmed]
  20. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. Specht, C.G., Schoepfer, R. BMC neuroscience [electronic resource]. (2001) [Pubmed]
  21. alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice. Shirakashi, Y., Kawamoto, Y., Tomimoto, H., Takahashi, R., Ihara, M. Acta Neuropathol. (2006) [Pubmed]
  22. Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein. Drolet, R.E., Behrouz, B., Lookingland, K.J., Goudreau, J.L. J. Neurochem. (2006) [Pubmed]
  23. Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra. von Bohlen und Halbach, O., Minichiello, L., Unsicker, K. FASEB J. (2005) [Pubmed]
  24. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., Mucke, L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  25. Unexpected Rescue of Alpha-synuclein and Multimerin1 Deletion in C57BL/6JOlaHsd Mice by Beta-adducin Knockout. Gajović, S., Mitrecić, D., Augustincić, L., Iaconcig, A., Muro, A.F. Transgenic Res. (2006) [Pubmed]
  26. Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Kallhoff, V., Peethumnongsin, E., Zheng, H. Molecular neurodegeneration (2007) [Pubmed]
  27. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.H., Castillo, P.E., Shinsky, N., Verdugo, J.M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D., Rosenthal, A. Neuron (2000) [Pubmed]
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