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Gene Review:

GPR137B - G protein-coupled receptor 137B

Homo sapiens

Synonyms: Integral membrane protein GPR137B, TM7SF1, Transmembrane 7 superfamily member 1 protein

Spangenberg, C. et al.

Spangenberg, Winterpacht, Zabel, Löbbert,

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High impact information on GPR137B

Studies on Wilms tumor samples showed variable TM7SF1 expression, ranging from nearly undetectable levels to an abundant level of expression comparable to that of adult kidney tissue [1].
By the use of single-chromosome hybrid cells and fluorescence in situ hybridization experiments, TM7SF1 could be localized to chromosome 1q42-q43 [1].
The full-length cDNA of TM7SF1 is about 2.4 kb and contains an open reading frame of 1197 nucleotides [1].

Analytical, diagnostic and therapeutic context of GPR137B

Human multiple tissue Northern blot analysis revealed TM7SF1 transcripts in human kidney, heart, brain, and placenta tissue [1].

References

Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. Spangenberg, C., Winterpacht, A., Zabel, B.U., Löbbert, R.W. Genomics (1998) [Pubmed]

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