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Gene Review

TOP1P2  -  topoisomerase (DNA) I pseudogene 2

Homo sapiens

 
 
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High impact information on TOP1P2

  • A TaqI RFLP at the human TOP1 pseudogene locus on chromosome 22q11.2-13.1 (TOP1P2) [1].
  • The Top-1ps locus, together with the immunoglobulin-lambda-light-chain locus, defines an additional conserved linkage group common to murine Chr 16 and human Chr 22, the site of the human pseudogene TOP1P2 [2].
  • Increased loss of heterozygosity during tumor progression or recurrence was seen in two patients at the D22S300 (q12.1-q13.1) and TOP1P2 (q11.2-q13.1) loci [3].

References

  1. A TaqI RFLP at the human TOP1 pseudogene locus on chromosome 22q11.2-13.1 (TOP1P2). Auerbach, A.D., Allen, R.G., Mann, W.R. Nucleic Acids Res. (1991) [Pubmed]
  2. Mouse genes encoding DNA topoisomerase I. Baumgärtner, B., Klett, C., Hameister, H., Richter, A., Knippers, R. Mamm. Genome (1994) [Pubmed]
  3. Chromosome 22q allelic losses at microsatellite loci in human astrocytic tumors. Muhammad, A.K., Yoshimine, T., Maruno, M., Tokiyoshi, K., Takemoto, O., Hayakawa, T. Neurol. Med. Chir. (Tokyo) (1997) [Pubmed]
 
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