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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sval1  -  seminal vesicle antigen-like 1

Mus musculus

Synonyms: 9130404C18Rik, SLP-C
 
 
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Disease relevance of Sval1

  • At 0.06 mumoles, streptovarone, Sval C, and SvD showed 78,62, and 29% inhibition of splenomegaly, respectively; SvA and SvC were essentially inactive [1].
 

High impact information on Sval1

  • The three homologous genes coding for SVA, SLP-C, and SLP-M may have been generated by gene duplication with divergence of tissue expression in the course of evolution [2].
  • RT-PCR analysis showed selective expression in the colon, and thus the protein was tentatively named "SVA-like protein in the colon (SLP-C)". The other mouse gene has an open reading frame encoding 144 amino acid residues with 46 and 65% identity to SVA and SLP-C, respectively [2].

References

  1. Effects of streptovaricins and their degradation products on infectivity of Rauscher leukemia virus. Li, L.H., Clark, T.D., Cowie, C.H., Swenberg, J.A., Renis, H.E., Rinehart, K.L. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: a gene family including the gene for prolactin-inducible protein. Yoshida, M., Kaneko, M., Kurachi, H., Osawa, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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