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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rspo3  -  R-spondin 3 homolog (Xenopus laevis)

Mus musculus

Synonyms: 2810459H04Rik, AW742308, Cabriolet, Cristin-1, Cristin1, ...
 
 
 
 
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High impact information on Rspo3

  • Furthermore, Cristin/R-spondin proteins possess an intriguing positive modulatory activity on Wnt ligands, possibly through a direct interaction [1].
  • Second, stimulation of cells with Cristin/R-spondin was accompanied by stabilization of endogenous beta-catenin proteins and induction of canonical Wnt target genes [1].

References

  1. Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate beta-Catenin-dependent Gene Expression. Nam, J.S., Turcotte, T.J., Smith, P.F., Choi, S., Yoon, J.K. J. Biol. Chem. (2006) [Pubmed]
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